PRPF3 and CCDC125

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRPF3	CCDC125
Description		pre-mRNA processing factor 3	coiled-coil domain containing 125
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Nuclear Speck Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome	Cytoplasm
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Negative Regulation Of Rho Protein Signal Transduction Activation Of GTPase Activity Regulation Of Cell Motility Negative Regulation Of Cell Motility
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Alanine aminotransferase levels ( 33339817) Ambidextrousness ( 32989287) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 30498476) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)	Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		50 interacting genes: BRCA1 CARD10 CASK CCDC125 CCDC136 CCDC85B CDC5L CEBPA CEP70 CTNNBL1 DPY30 DVL2 DVL3 FAM9B FCHO1 FRA10AC1 GOLGA2 GPRASP2 GTPBP3 HSF2BP LZTS1 MAPRE1 MID2 NACC1 NAV2 NINL NKAP NKAPD1 OSBPL3 PCBP1 PHC2 PIP4K2B PRPF31 PSMD3 RABEP1 RNF151 SART3 SHKBP1 SNIP1 SNRNP200 SSX2IP TRIM39 TSPYL1 TXLNA USP4 WBP4 ZBTB8A ZCCHC10 ZFPM2 ZGPAT	64 interacting genes: AIRIM ATOSB BMP7 C21orf58 C22orf15 CCNG1 CDC23 CDK18 CEP95 DRC4 EIF3D FAM107A FAM161A FAM161B FAM47B FLYWCH1 GEM HAPLN2 HDAC4 KAT5 KIF9 KRTAP13-2 LCE2C MYH1 NEBL NSD1 NSMF OTOS PKP2 PRPF3 PTPA RAB2A RIPOR3 SFN SNW1 SPMIP2 STX11 TCHP TEAD4 TRIM14 TSGA10IP UACA YWHAE YWHAH YWHAQ YWHAZ ZFP1 ZFYVE26 ZNF165 ZNF230 ZNF250 ZNF32 ZNF337 ZNF343 ZNF417 ZNF436 ZNF552 ZNF557 ZNF564 ZNF587 ZNF764 ZNF792 ZNF837 ZNF883
Entrez ID		9129	202243
HPRD ID		07389	13774
Ensembl ID		ENSG00000117360	ENSG00000183323
Uniprot IDs		O43395	B4DSR1 Q2HJ12 Q86Z20
PDB IDs		1X4Q 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7N2N 7N2R 7N2S 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Identical Protein Binding RNA Splicing Spliceosomal Complex U2-type Precatalytic Spliceosome Spliceosomal Tri-snRNP Complex Assembly Nucleus MRNA Processing Hematopoietic Stem Cell Proliferation Nucleoplasm Protein Binding U4 SnRNA Binding Positive Regulation Of Neuron Projection Arborization U4/U6 X U5 Tri-snRNP Complex Spliceosomal SnRNP Assembly Protein-RNA Complex Assembly MRNA Metabolic Process Centrosome Cycle Protein Domain Specific Binding RNA Metabolic Process Prp19 Complex RNA Processing Protein Localization To Microtubule Cytoplasm Protein-containing Complex Assembly Regulation Of Neuron Projection Arborization	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Phosphoserine Residue Binding Zinc Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Binding Transmembrane Transporter Binding
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