PRPF3 and SART3

Number of citations of the paper that reports this interaction (PubMedID 15452143)
52

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PRPF3	SART3
Description		pre-mRNA processing factor 3	spliceosome associated factor 3, U4/U6 recycling protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Nuclear Speck Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome	Nucleus Nucleoplasm U6atac SnRNP Cytoplasm Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex ASAP Complex U4/U6 SnRNP U4atac/U6atac SnRNP
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding U6 SnRNA Binding U4 SnRNA Binding U6atac SnRNA Binding Protein-macromolecule Adaptor Activity Histone Binding Ubiquitin-specific Protease Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Cell Morphogenesis Nucleosome Assembly RNA Processing MRNA Processing RNA Splicing Regulation Of Gene Expression Homeostasis Of Number Of Cells Regulation Of RNA Metabolic Process Hematopoietic Stem Cell Proliferation Transcription Elongation-coupled Chromatin Remodeling
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)	Disseminated superficial actinic porokeratosis (DSAP)
GWAS		Alanine aminotransferase levels ( 33339817) Ambidextrousness ( 32989287) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 30498476) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)	Acne (severe) ( 24927181)
Interacting Genes		50 interacting genes: BRCA1 CARD10 CASK CCDC125 CCDC136 CCDC85B CDC5L CEBPA CEP70 CTNNBL1 DPY30 DVL2 DVL3 FAM9B FCHO1 FRA10AC1 GOLGA2 GPRASP2 GTPBP3 HSF2BP LZTS1 MAPRE1 MID2 NACC1 NAV2 NINL NKAP NKAPD1 OSBPL3 PCBP1 PHC2 PIP4K2B PRPF31 PSMD3 RABEP1 RNF151 SART3 SHKBP1 SNIP1 SNRNP200 SSX2IP TRIM39 TSPYL1 TXLNA USP4 WBP4 ZBTB8A ZCCHC10 ZFPM2 ZGPAT	29 interacting genes: AR C6 COIL CTBP1 H2AC20 H2BC21 MEGF10 MIR1-1 MIR128-2 MIR143 MIR18A MIR18B MIR19B2 MIR200B MIR200C MIR221 MIR34A MIR34B MIR7-1 MIR7-3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 PRPF3 RNF10 RNPS1 ZNF620 ZNF71
Entrez ID		9129	9733
HPRD ID		07389	11532
Ensembl ID		ENSG00000117360	ENSG00000075856
Uniprot IDs		O43395	A0A499FI31 Q15020
PDB IDs		1X4Q 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7N2N 7N2R 7N2S 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O	2DO4 5CTQ 5CTR 5CTT 5JJW 5JJX 5JPZ 7XX8 7XX9
Enriched GO Terms of Interacting Partners?		RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Identical Protein Binding RNA Splicing Spliceosomal Complex U2-type Precatalytic Spliceosome Spliceosomal Tri-snRNP Complex Assembly Nucleus MRNA Processing Hematopoietic Stem Cell Proliferation Nucleoplasm Protein Binding U4 SnRNA Binding Positive Regulation Of Neuron Projection Arborization U4/U6 X U5 Tri-snRNP Complex Spliceosomal SnRNP Assembly Protein-RNA Complex Assembly MRNA Metabolic Process Centrosome Cycle Protein Domain Specific Binding RNA Metabolic Process Prp19 Complex RNA Processing Protein Localization To Microtubule Cytoplasm Protein-containing Complex Assembly Regulation Of Neuron Projection Arborization	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MRNA Destabilization Negative Regulation Of Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of Sprouting Angiogenesis Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Macromolecule Metabolic Process Regulation Of Muscle Cell Differentiation Regulation Of Angiogenesis Regulation Of Smooth Muscle Cell Differentiation Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Transmembrane Transport Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-33 Production Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Signal Transduction Extracellular Vesicle Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Developmental Process Negative Regulation Of Cytokine Production Regulation Of Endothelial Cell Migration
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