PRPF3 and TRIM39

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRPF3	TRIM39
Gene Name		pre-mRNA processing factor 3	tripartite motif containing 39
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex	Mitochondrion Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Poly(A) RNA Binding	Protein Binding Zinc Ion Binding Ligase Activity Identical Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Apoptotic Process Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: BRCA1 CCDC85B CDC5L CTNNBL1 DPY30 DVL2 DVL3 FAM9B FRA10AC1 GTPBP3 NHP2L1 NKAP PCBP1 PPIH PRPF31 PRPF4 RBM39 SART3 SNIP1 TRIM39 U2AF2 USP4 WBP4 ZCCHC10	52 interactors: APP CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 KDM1A LNX1 LXN MED18 MNAT1 OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMD9 RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1 UBTD2 UBXN1 UBXN6 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26
Entrez ID		9129	56658
HPRD ID		07389	09298
Ensembl ID		ENSG00000117360	ENSG00000204599
Uniprot IDs		E7EVD1 O43395	Q9HCM9
PDB IDs		1X4Q	2DID 2DIF 2ECJ
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Spliceosomal Tri-snRNP Complex Assembly Cellular Metabolic Process Spliceosomal SnRNP Assembly Hematopoietic Stem Cell Proliferation Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Wnt Signaling Pathway, Planar Cell Polarity Pathway Ribonucleoprotein Complex Biogenesis Metabolic Process Cochlea Morphogenesis Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Ribonucleoprotein Complex Assembly Regulation Of Protein Ubiquitination Cochlea Development Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone Deubiquitination Positive Regulation Of Histone H4-K16 Acetylation Outflow Tract Morphogenesis Positive Regulation Of Histone Modification Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of JUN Kinase Activity Cellular Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of JUN Kinase Activity Stem Cell Proliferation Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Signal Transduction In Response To DNA Damage RNA Biosynthetic Process Canonical Wnt Signaling Pathway Regulation Of Metabolic Process Inner Ear Morphogenesis Negative Regulation Of Protein Ubiquitination Non-canonical Wnt Signaling Pathway Via JNK Cascade	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Proteolysis Regulation Of Protein Ubiquitination Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Toll-like Receptor 4 Signaling Pathway Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Toll-like Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Response To Stress Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Activation Of Innate Immune Response
Tagcloud ?		accumulative assumes debilitating decades degeneration developmentally example focused hypotheses hypothesis implying interacting interrupt intriguing metabolically methodology mildly phenomenon photoreceptors principal prp31 prpc8 retina retinal rp18 snrnas splicing suboptimal ubiquitously	293t aeromonas aggregate b30 bloodthirsty btr18 btr20 btr21 btr22 danio deduced e3 gill hydrophila intestine ligase mentioned multigene nj rbcc remarkably rerio tripartite ubch6 ubiquitin ubiquitylated ubiquitylation zebrafish
Tagcloud (Difference) ?		accumulative assumes debilitating decades degeneration developmentally example focused hypotheses hypothesis implying interacting interrupt intriguing metabolically methodology mildly phenomenon photoreceptors principal prp31 prpc8 retina retinal rp18 snrnas splicing suboptimal ubiquitously	293t aeromonas aggregate b30 bloodthirsty btr18 btr20 btr21 btr22 danio deduced e3 gill hydrophila intestine ligase mentioned multigene nj rbcc remarkably rerio tripartite ubch6 ubiquitin ubiquitylated ubiquitylation zebrafish
Tagcloud (Intersection) ?