MYEF2 and PLEKHG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYEF2	PLEKHG4
Description		myelin expression factor 2	pleckstrin homology and RhoGEF domain containing G4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Myotube Differentiation Neuron Differentiation	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction
Pathways			RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Skin pigmentation ( 28300201)	A body shape index ( 34021172) Heel bone mineral density ( 28869591) High density lipoprotein cholesterol levels ( 33339817) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		41 interacting genes: COG8 GOLGA2 LNX1 MIR128-2 MIR141 MIR15A MIR17 MIR19B1 MIR19B2 MIR200A MIR20A MIR20B MIR21 MIR221 MIR25 MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR429 MIR9-1 MIR9-2 MIR93 MIRLET7A3 MIRLET7B MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I NFKBID OGT OIP5 PLEKHG4 TEX11 TRAF1 TRIM23 ZRANB1	65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13B FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SAXO4 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648
Entrez ID		50804	25894
HPRD ID		14794	10890
Ensembl ID		ENSG00000104177	ENSG00000196155
Uniprot IDs		A0A0A0MQW0 Q9P2K5	A0A024R6X4 Q58EX7
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Vesicle MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Vascular Endothelial Growth Factor Production MRNA Destabilization RNA Destabilization Regulation Of Gene Expression Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Translation Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Macromolecule Metabolic Process Extracellular Space Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Developmental Process Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Anatomical Structure Morphogenesis	Protein Binding Regulation Of Podosome Assembly Positive Regulation Of Ureteric Bud Formation
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