SESN1 and PRDX1

Number of citations of the paper that reports this interaction (PMID 15105503)
135

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SESN1	PRDX1
Gene Name		sestrin 1	peroxiredoxin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Space Nucleus Nuclear Euchromatin Nucleolus Cytoplasm Mitochondrial Matrix Peroxisomal Matrix Cytosol Melanosome Extracellular Vesicular Exosome
	Molecular Function		Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Heme Binding Protein Homodimerization Activity Poly(A) RNA Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Negative Regulation Of Cell Proliferation Regulation Of Protein Kinase B Signaling Regulation Of Response To Reactive Oxygen Species	Response To Reactive Oxygen Species Skeletal System Development Retina Homeostasis Cell Proliferation Removal Of Superoxide Radicals Regulation Of Stress-activated MAPK Cascade Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Regulation Of NF-kappaB Import Into Nucleus Hydrogen Peroxide Catabolic Process Oxidation-reduction Process
Pathways			Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		1 interactors: PRDX1	24 interactors: ABL1 ADH5 BTRC CALM1 CLEC4G EGFR GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ
Entrez ID		27244	5052
HPRD ID		07310	01458
Ensembl ID		ENSG00000080546	ENSG00000117450
Uniprot IDs		Q9Y6P5	Q06830
PDB IDs			2RII 3HY2
Enriched GO Terms of Interacting Partners?		Hydrogen Peroxide Catabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Response To Superoxide Response To Oxygen Radical Leukocyte Mediated Cytotoxicity Hydrogen Peroxide Metabolic Process Regulation Of NF-kappaB Import Into Nucleus Superoxide Metabolic Process Retina Homeostasis Regulation Of Transcription Factor Import Into Nucleus Cellular Response To Reactive Oxygen Species Reactive Oxygen Species Metabolic Process Erythrocyte Homeostasis Myeloid Cell Homeostasis Regulation Of Protein Import Into Nucleus Tissue Homeostasis Regulation Of Stress-activated MAPK Cascade Response To Reactive Oxygen Species Regulation Of Protein Localization To Nucleus Cellular Response To Oxidative Stress Regulation Of Nucleocytoplasmic Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Multicellular Organismal Homeostasis Homeostasis Of Number Of Cells Regulation Of Intracellular Protein Transport Leukocyte Mediated Immunity Response To Oxidative Stress Regulation Of Intracellular Transport Response To Inorganic Substance Skeletal System Development Regulation Of MAPK Cascade Regulation Of Protein Transport	Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Response To Organic Substance Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Regulation Of Oxidoreductase Activity Positive Regulation Of Apoptotic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Response To Stimulus Positive Regulation Of Cell Death Regulation Of Phospholipase Activity Apoptotic Process Programmed Cell Death Intracellular Signal Transduction Cellular Response To Organic Substance Cell Death Death Regulation Of Response To Reactive Oxygen Species Regulation Of Cellular Ketone Metabolic Process Peptidyl-cysteine S-nitrosylation Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Oxidoreductase Activity Response To Lipid Regulation Of Protein Stability Response To Lipopolysaccharide Developmental Process Positive Regulation Of Signal Transduction Response To Molecule Of Bacterial Origin Cellular Response To Growth Factor Stimulus Type I Interferon Biosynthetic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Response To Growth Factor Regulation Of Cell Cycle Cellular Response To Stimulus Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Organic Cyclic Compound Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Phosphorylation Cell Cycle Process Response To Fibroblast Growth Factor
Tagcloud ?		bindingprotein blockade condition deprivation diphosphate e3 eliminates ern1 finction finger glioma glutamine matrin nm23 nme nme6 nucleoside ofrybpi oftumor regulatedpa26 rybp topoisomerase topors tp53 tp53bp1 tp53bpi tp53tg1 u87 zmat3	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?		bindingprotein blockade condition deprivation diphosphate e3 eliminates ern1 finction finger glioma glutamine matrin nm23 nme nme6 nucleoside ofrybpi oftumor regulatedpa26 rybp topoisomerase topors tp53 tp53bp1 tp53bpi tp53tg1 u87 zmat3	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?