FURIN and ASH2L

		FURIN	ASH2L
Description		furin, paired basic amino acid cleaving enzyme	ASH2 like, histone lysine methyltransferase complex subunit
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endosome Endoplasmic Reticulum Golgi Apparatus Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle Organelle Membrane Membrane Raft Extracellular Exosome Golgi Apparatus Subcompartment	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding Endopeptidase Activator Activity Heparan Sulfate Binding	Transcription Cis-regulatory Region Binding DNA Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Blastocyst Formation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signal Peptide Processing Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Protein Processing Peptide Hormone Processing Viral Life Cycle Viral Translation Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Zymogen Activation Regulation Of Cholesterol Transport Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Plasma Lipoprotein Particle Remodeling Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Positive Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Dibasic Protein Processing Zymogen Inhibition Cytokine Precursor Processing Amyloid Fibril Formation	Chromatin Organization DNA Damage Response Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Hemopoiesis Response To Estrogen Transcription Initiation-coupled Chromatin Remodeling
Pathways		Signaling by NODAL Collagen degradation Collagen degradation Elastic fibre formation Activation of Matrix Metalloproteinases Removal of aminoterminal propeptides from gamma-carboxylated proteins NGF processing Synthesis and processing of ENV and VPU Signaling by PDGF Pre-NOTCH Processing in Golgi TGF-beta receptor signaling activates SMADs SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Uptake and function of anthrax toxins Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes CD163 mediating an anti-inflammatory response Potential therapeutics for SARS Attachment and Entry Induction of Cell-Cell Fusion Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry Maturation of hRSV A proteins	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs		Capric acid
Diseases
GWAS		Age at first sexual intercourse ( 34211149 27089180) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 34002096) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 32469254 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) General risk tolerance (MTAG) ( 30643258) Hypertension ( 21909115 30487518) Language functional connectivity ( 34929384) Left-handedness ( 32989287) Mean arterial pressure ( 27618448 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 26343387) Neutrophil count ( 32888494) Offspring birth weight ( 31043758) Parental lifespan ( 30642433) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 29483656 30285260 25056061) Systolic blood pressure ( 28739976 28135244 27618452 29403010 26390057 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White blood cell count ( 32888494)	Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656) Venous thromboembolism ( 33592630)
Interacting Genes		29 interacting genes: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 BACE1 CNMD COL23A1 DSG3 EDA FLNA FLNC ITM2C LRP1 MMP14 NAGPA NAPA NOTCH1 PACS1 PDGFA PMCH PRB4 SERPINB8 SORCS1 SORL1 TNFSF13 VWF ZP3 ZP4	34 interacting genes: ACTC1 ACTN2 ANKRD1 BARD1 BRCA1 CCNC CEP76 COPS6 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 MESD MKRN1 MYBPC1 MYOM3 PPP1CC PRMT1 RBM39 SMAD9 SMURF1 SMURF2 TGFBR1 TTN UNC119 WWP1 ZSCAN1
Entrez ID		5045	9070
HPRD ID		00653	05309
Ensembl ID		ENSG00000140564	ENSG00000129691
Uniprot IDs		P09958	B4DPT1 F5H8F7 Q9UBL3
PDB IDs		4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ 5MIM 6A8Y 6EQV 6EQW 6EQX 6HLB 6HLD 6HLE 6HZA 6HZB 6HZC 6HZD 6YD2 6YD3 6YD4 6YD7 7LCU 7O1U 7O1W 7O1Y 7O20 7O22 7QXY 7QXZ 7QY0 7QY1 7QY2 8B4V 8B4W 8B4X 8OYH	3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ 6PWV 6W5I 6W5M 6W5N 7BRE 7MBM 7MBN 7UD5 7W67 7W6A 7W6I 7W6J 7W6L
Enriched GO Terms of Interacting Partners?		Extracellular Region Regulation Of Cell Motility Regulation Of Locomotion Extracellular Matrix Regulation Of Cell Migration Amyloid Precursor Protein Catabolic Process Extracellular Space Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Humoral Immune Response Regulation Of Smooth Muscle Cell Migration Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Acrosin Binding Negative Regulation Of Binding Of Sperm To Zona Pellucida Structural Constituent Of Egg Coat Egg Coat Positive Regulation Of Cell Motility Regulation Of Cell Population Proliferation Positive Regulation Of Locomotion Amyloid-beta Binding Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Gene Expression Metalloendopeptidase Activity Cellular Developmental Process Regulation Of Glial Cell Proliferation Positive Regulation Of Acrosome Reaction Regulation Of Cellular Localization Regulation Of Humoral Immune Response Lysosomal Transport Plasma Membrane Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Cell Activation Negative Regulation Of Neurogenesis Metallopeptidase Activity Amyloid-beta Formation Transmembrane Transporter Binding Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Nervous System Development Integrin Binding Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Mononuclear Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Developmental Process Regulation Of Acrosome Reaction Gene Expression	Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Histone Methyltransferase Complex MLL1/2 Complex Epigenetic Regulation Of Gene Expression Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Sarcomere Organization Regulation Of Gene Expression I-SMAD Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Actomyosin Structure Organization Protein-containing Complex Histone H3K4 Monomethyltransferase Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K4 Trimethyltransferase Activity Nucleoplasm Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Regulation Of Primary Metabolic Process Titin Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Condensed Nuclear Chromosome SMAD Binding Transcription Initiation-coupled Chromatin Remodeling Histone H3K4 Methyltransferase Activity Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Positive Regulation Of Gene Expression, Epigenetic Cardiac Muscle Tissue Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Muscle Tissue Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription M Band I Band Response To Muscle Stretch Positive Regulation Of Gene Expression Positive Regulation Of Nucleobase-containing Compound Metabolic Process BRCA1-B Complex Transferase Activity R-SMAD Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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