ZP3

Description		zona pellucida glycoprotein 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Matrix Egg Coat
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding Receptor Ligand Activity
	Biological Process	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Signal Transduction Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-4 Production Egg Coat Formation Positive Regulation Of T Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth
Pathways		Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS		Parkinson disease and lewy body pathology ( 25663231)
Interacting Genes		11 interacting genes: ACR CLDN11 ENGASE FURIN MALL MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L
Entrez ID		7784
HPRD ID		01690
Ensembl ID		ENSG00000188372
Uniprot IDs		P21754
PDB IDs
Enriched GO Terms of Interacting Partners?		Acrosomal Matrix Sperm-egg Recognition Cell-cell Recognition Cell Recognition Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Mannosyl-glycoprotein Endo-beta-N-acetylglucosaminidase Activity Cytoplasmic Side Of Endosome Membrane Amidase Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Slow Endocytic Recycling Axon Ensheathment Negative Regulation Of Receptor Catabolic Process Presynaptic Active Zone Assembly Protease Binding Acrosomal Vesicle Viral Translation Viral Life Cycle Serine-type Peptidase Activity Plasma Membrane Organization Cytokine Precursor Processing Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Synaptic Vesicle Clustering Serine-type Endopeptidase Activity Fucose Binding Positive Regulation Of Stress Granule Assembly Lysozyme Activity
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