ZP3 and PCDH17

Number of citations of the paper that reports this interaction (PMID 19945174)
4

Data Source:
BioGRID (two hybrid)

		ZP3	PCDH17
Gene Name		zona pellucida glycoprotein 3 (sperm receptor)	protocadherin 17
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Outer Acrosomal Membrane Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Extracellular Matrix Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signal Transducer Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Store-operated Calcium Channel Activity Carbohydrate Binding Acrosin Binding	Calcium Ion Binding Protein Binding
	Biological Process	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Manganese Ion Transport Intracellular Protein Transport Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Multicellular Organism Reproduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Egg Coat Formation Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylinositol-mediated Signaling Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Protein Kinase C Signaling Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Import Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Pathways		Interaction With The Zona Pellucida Fertilization
Drugs
Diseases
GWAS			Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		9 interactors: ACR ENGASE FURIN MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L	3 interactors: NR1H2 UBQLN4 ZP3
Entrez ID		7784	27253
HPRD ID		01690	15104
Ensembl ID		ENSG00000188372	ENSG00000118946
Uniprot IDs		P21754	O14917
PDB IDs
Enriched GO Terms of Interacting Partners?		Sperm-egg Recognition Cell-cell Recognition Cell Recognition Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Slow Endocytic Recycling Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Cell Wall Macromolecule Catabolic Process Sexual Reproduction Monocyte Activation Protein Localization To Endosome Peptidoglycan Catabolic Process Retrograde Transport, Endosome To Plasma Membrane Viral Protein Processing Positive Regulation Of Macrophage Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Reproduction	Positive Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth Positive Regulation Of Type IV Hypersensitivity Egg Coat Formation Regulation Of High-density Lipoprotein Particle Assembly Regulation Of Ovarian Follicle Development Negative Regulation Of Binding Of Sperm To Zona Pellucida Negative Regulation Of Pinocytosis Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Secretion Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Acrosome Reaction Positive Regulation Of Phospholipid Biosynthetic Process Regulation Of Vesicle-mediated Transport Regulation Of Protein Metabolic Process Negative Regulation Of Cholesterol Storage Positive Regulation Of Hypersensitivity Positive Regulation Of Digestive System Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Manganese Ion Transmembrane Transport Regulation Of Acrosome Reaction Manganese Ion Transport Regulation Of Female Gonad Development Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Calcium Ion Import Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Homeostasis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Positive Regulation Of Humoral Immune Response Regulation Of Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Proteolysis Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Transport
Tagcloud ?		blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic
Tagcloud (Difference) ?		blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic
Tagcloud (Intersection) ?