P2RX3 and P2RX2

Number of citations of the paper that reports this interaction (PMID 7566120)
161

Data Source:
HPRD (in vitro)

		P2RX3	P2RX2
Gene Name		purinergic receptor P2X, ligand gated ion channel, 3	purinergic receptor P2X, ligand gated ion channel, 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Rough Endoplasmic Reticulum Golgi Apparatus Integral Component Of Plasma Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Receptor Complex Membrane Raft	Integral Component Of Nuclear Inner Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Apical Plasma Membrane Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Receptor Complex
	Molecular Function	Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity ATP Binding	Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Copper Ion Binding ATP Binding Drug Binding Zinc Ion Binding Ligand-gated Ion Channel Activity Nickel Cation Binding Phosphatidylinositol Binding Identical Protein Binding Mercury Ion Binding Cadmium Ion Binding Cobalt Ion Binding
	Biological Process	Response To Hypoxia Transport Signal Transduction Neuromuscular Synaptic Transmission Response To Heat Response To Cold Response To Mechanical Stimulus Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Neuronal Action Potential Peristalsis Response To ATP Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Synaptic Plasticity Behavioral Response To Pain Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Protein Homooligomerization Cation Transmembrane Transport	Response To Hypoxia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Neuromuscular Synaptic Transmission Neuromuscular Junction Development Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Neuronal Action Potential Peristalsis Response To ATP Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Protein Homooligomerization Protein Heterooligomerization Cation Transmembrane Transport
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: P2RX2	3 interactors: GABRR1 P2RX1 P2RX3
Entrez ID		5024	22953
HPRD ID		09016	15984
Ensembl ID			ENSG00000187848
Uniprot IDs		P56373	Q32MC3 Q9UBL9
PDB IDs
Enriched GO Terms of Interacting Partners?		Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Urinary Bladder Smooth Muscle Contraction Peristalsis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Behavioral Response To Pain Skeletal Muscle Fiber Development Neuromuscular Synaptic Transmission Response To ATP Positive Regulation Of Calcium-mediated Signaling Myotube Cell Development Neuronal Action Potential Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Response To Pain Regulation Of Calcium-mediated Signaling Muscle Fiber Development Neuromuscular Junction Development Transmission Of Nerve Impulse Myotube Differentiation Smooth Muscle Contraction Sensory Perception Of Taste Regulation Of Calcium Ion Transport Into Cytosol Action Potential Multicellular Organismal Response To Stress Positive Regulation Of Calcium Ion Transport Regulation Of Systemic Arterial Blood Pressure Protein Heterooligomerization Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Response To Organophosphorus Sensory Perception Of Sound Striated Muscle Cell Development Regulation Of Ion Homeostasis Muscle Cell Development Synapse Organization Response To Purine-containing Compound Regulation Of Blood Pressure Sensory Perception Of Mechanical Stimulus Response To Carbohydrate Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Muscle Contraction Striated Muscle Cell Differentiation Positive Regulation Of Intracellular Transport Protein Homooligomerization Muscle System Process Regulation Of Membrane Potential Muscle Organ Development Response To Hypoxia Blood Circulation	Response To ATP Neuronal Action Potential Purinergic Nucleotide Receptor Signaling Pathway Synaptic Transmission Transmission Of Nerve Impulse Action Potential Cell-cell Signaling Response To Organophosphorus Response To Purine-containing Compound Ion Transmembrane Transport Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Protein Homooligomerization Serotonin Secretion By Platelet Inorganic Anion Transport Regulation Of Membrane Potential Transmembrane Transport Ion Transport Serotonin Secretion Regulation Of Vascular Smooth Muscle Contraction Serotonin Transport Protein Oligomerization Urinary Bladder Smooth Muscle Contraction Peristalsis Regulation Of Ion Transport Insemination Anion Transport Cell Surface Receptor Signaling Pathway Behavioral Response To Pain Copulation Positive Regulation Of Transport Neuromuscular Synaptic Transmission Monoamine Transport Positive Regulation Of Calcium-mediated Signaling Production Of Molecular Mediator Involved In Inflammatory Response Response To Organonitrogen Compound Gamma-aminobutyric Acid Signaling Pathway Response To Organic Cyclic Compound Vasoconstriction Cation Transmembrane Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Response To Pain Synaptic Transmission, Glutamatergic Regulation Of Calcium-mediated Signaling Protein Complex Assembly Ceramide Biosynthetic Process Mating Regulation Of Smooth Muscle Contraction Neurological System Process Response To Cold
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