P2RX3

Description		purinergic receptor P2X 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Neuron Projection Receptor Complex Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynapse
	Molecular Function	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity ATP Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Monoatomic Ion Transport Monoatomic Cation Transport Signal Transduction Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Response To Temperature Stimulus Response To Heat Response To Cold Response To Mechanical Stimulus Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Synaptic Plasticity Behavioral Response To Pain Modulation Of Chemical Synaptic Transmission Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Establishment Of Localization In Cell Excitatory Postsynaptic Potential Protein Homotrimerization Calcium Ion Transmembrane Transport Cellular Response To ATP Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis
Drugs		Promethazine
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Eosinophil percentage of white cells ( 27863252) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Low high density lipoprotein cholesterol levels ( 26879886) Triglyceride levels ( 32203549)
Interacting Genes		1 interacting genes: P2RX2
Entrez ID		5024
HPRD ID		09016
Ensembl ID		ENSG00000109991
Uniprot IDs		P56373
PDB IDs		5SVJ 5SVK 5SVL 5SVM 5SVP 5SVQ 5SVR 5SVS 5SVT 5YVE 6AH4 6AH5 9IK1
Enriched GO Terms of Interacting Partners?		Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Urinary Bladder Smooth Muscle Contraction Purinergic Nucleotide Receptor Activity Peristalsis Extracellularly ATP-gated Monoatomic Cation Channel Activity Positive Regulation Of Calcium Ion Transport Into Cytosol Purinergic Nucleotide Receptor Signaling Pathway Neuronal Dense Core Vesicle Regulation Of Calcium Ion Transport Into Cytosol Behavioral Response To Pain Skeletal Muscle Fiber Development Sensory Perception Of Taste Ligand-gated Monoatomic Ion Channel Activity Response To ATP Neuromuscular Synaptic Transmission Myotube Cell Development Neuromuscular Junction Development Smooth Muscle Contraction Positive Regulation Of Calcium-mediated Signaling Excitatory Postsynaptic Potential Response To Ischemia Positive Regulation Of Calcium Ion Transmembrane Transport Striated Muscle Cell Development Muscle Cell Development Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Regulation Of Postsynaptic Membrane Potential Sensory Perception Of Chemical Stimulus Detection Of Chemical Stimulus Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Response To Carbohydrate Monoatomic Ion Channel Activity Positive Regulation Of Monoatomic Ion Transport Receptor Complex Calcium Ion Transmembrane Transport Muscle Contraction Regulation Of Calcium Ion Transport Postsynapse Muscle System Process Detection Of Stimulus Calcium Ion Transport Synapse Organization Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport
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