P2RX1 and P2RX2

Number of citations of the paper that reports this interaction (PubMedID 15313628)
0

Data Source:
HPRD (in vitro)

		P2RX1	P2RX2
Description		purinergic receptor P2X 1	purinergic receptor P2X 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane Protein-containing Complex Specific Granule Membrane Membrane Raft Postsynaptic Membrane Presynaptic Active Zone Membrane Glutamatergic Synapse	Plasma Membrane Membrane Apical Plasma Membrane Neuronal Cell Body Receptor Complex Synapse Postsynapse Neuronal Dense Core Vesicle
	Molecular Function	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding ATP Binding Channel Activity Identical Protein Binding Suramin Binding Protein-containing Complex Binding Ligand-gated Calcium Channel Activity	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity ATP Binding Ligand-gated Monoatomic Ion Channel Activity Identical Protein Binding
	Biological Process	Serotonin Secretion By Platelet Regulation Of Vascular Associated Smooth Muscle Contraction Monoatomic Ion Transport Apoptotic Process Regulation Of Smooth Muscle Contraction Signal Transduction Insemination Regulation Of Blood Pressure Neuronal Action Potential Regulation Of Vasoconstriction Calcium-mediated Signaling Platelet Activation Response To ATP Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Monoatomic Ion Transport Ceramide Biosynthetic Process Establishment Of Localization In Cell Regulation Of Calcium Ion Transport Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Synaptic Vesicle Exocytosis	Response To Hypoxia Response To Ischemia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Monoatomic Ion Transport Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Neuromuscular Junction Development Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis Neutrophil degranulation	Elevation of cytosolic Ca2+ levels Platelet homeostasis
Drugs		Promethazine	Promethazine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Body mass index ( 26426971)
Interacting Genes		2 interacting genes: CYBC1 P2RX2	4 interacting genes: GABRA1 GABRR1 P2RX1 P2RX3
Entrez ID		5023	22953
HPRD ID		07526	15984
Ensembl ID		ENSG00000108405	ENSG00000187848
Uniprot IDs		P51575	Q32MC3 Q9UBL9
PDB IDs		9B73 9B95 9C2A 9C2B 9C2C
Enriched GO Terms of Interacting Partners?		Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Urinary Bladder Smooth Muscle Contraction Purinergic Nucleotide Receptor Activity Peristalsis Extracellularly ATP-gated Monoatomic Cation Channel Activity Respiratory Burst Involved In Defense Response Respiratory Burst After Phagocytosis Positive Regulation Of Calcium Ion Transport Into Cytosol Purinergic Nucleotide Receptor Signaling Pathway Neuronal Dense Core Vesicle Regulation Of Calcium Ion Transport Into Cytosol Behavioral Response To Pain Respiratory Burst Skeletal Muscle Fiber Development Sensory Perception Of Taste Ligand-gated Monoatomic Ion Channel Activity Response To ATP Neuromuscular Synaptic Transmission Myotube Cell Development Neuromuscular Junction Development Smooth Muscle Contraction Positive Regulation Of Calcium-mediated Signaling Excitatory Postsynaptic Potential Response To Ischemia Positive Regulation Of Calcium Ion Transmembrane Transport Striated Muscle Cell Development	Monoatomic Ion Channel Activity Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Regulation Of Membrane Potential GABA Receptor Activity Regulation Of Postsynaptic Membrane Potential Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Cell-cell Signaling Signaling Cell Communication Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport GABA-gated Chloride Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Monoatomic Ion Transport Postsynaptic Membrane Purinergic Nucleotide Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Transmembrane Transport Response To ATP Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Complex Positive Regulation Of Calcium Ion Transmembrane Transport Excitatory Postsynaptic Potential Chloride Channel Activity Modulation Of Chemical Synaptic Transmission Chloride Transmembrane Transport Positive Regulation Of Calcium Ion Transport GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Suramin Binding Regulation Of Biological Quality GABA Receptor Complex Serotonin Secretion By Platelet Positive Regulation Of Monoatomic Ion Transport Calcium Ion Transmembrane Transport Serotonin Secretion Insemination
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