P2RX1

Description		purinergic receptor P2X 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane Protein-containing Complex Specific Granule Membrane Membrane Raft Postsynaptic Membrane Presynaptic Active Zone Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding ATP Binding Channel Activity Identical Protein Binding Suramin Binding Protein-containing Complex Binding Ligand-gated Calcium Channel Activity
	Biological Process	Serotonin Secretion By Platelet Regulation Of Vascular Associated Smooth Muscle Contraction Monoatomic Ion Transport Apoptotic Process Regulation Of Smooth Muscle Contraction Signal Transduction Insemination Regulation Of Blood Pressure Neuronal Action Potential Regulation Of Vasoconstriction Calcium-mediated Signaling Platelet Activation Response To ATP Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Monoatomic Ion Transport Ceramide Biosynthetic Process Establishment Of Localization In Cell Regulation Of Calcium Ion Transport Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Synaptic Vesicle Exocytosis
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis Neutrophil degranulation
Drugs		Promethazine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		2 interacting genes: CYBC1 P2RX2
Entrez ID		5023
HPRD ID		07526
Ensembl ID		ENSG00000108405
Uniprot IDs		P51575
PDB IDs		9B73 9B95 9C2A 9C2B 9C2C
Enriched GO Terms of Interacting Partners?		Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Urinary Bladder Smooth Muscle Contraction Purinergic Nucleotide Receptor Activity Peristalsis Extracellularly ATP-gated Monoatomic Cation Channel Activity Respiratory Burst Involved In Defense Response Respiratory Burst After Phagocytosis Positive Regulation Of Calcium Ion Transport Into Cytosol Purinergic Nucleotide Receptor Signaling Pathway Neuronal Dense Core Vesicle Regulation Of Calcium Ion Transport Into Cytosol Behavioral Response To Pain Respiratory Burst Skeletal Muscle Fiber Development Sensory Perception Of Taste Ligand-gated Monoatomic Ion Channel Activity Response To ATP Neuromuscular Synaptic Transmission Myotube Cell Development Neuromuscular Junction Development Smooth Muscle Contraction Positive Regulation Of Calcium-mediated Signaling Excitatory Postsynaptic Potential Response To Ischemia Positive Regulation Of Calcium Ion Transmembrane Transport Striated Muscle Cell Development
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