ORM1 and CCR5

Number of citations of the paper that reports this interaction (PMID 11336643)
5

Data Source:
HPRD (in vitro)

		ORM1	CCR5
Gene Name		orosomucoid 1	chemokine (C-C motif) receptor 5 (gene/pseudogene)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Protein Binding	Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Regulation Of Immune System Process Transport Acute-phase Response Inflammatory Response	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Viral Process Calcium-mediated Signaling Signaling Entry Into Host Cell Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs			Maraviroc
Diseases
GWAS		End-stage coagulation ( 23381943) Tourette syndrome ( 22889924)	Celiac disease ( 20190752)
Protein-Protein Interactions		9 interactors: ALB BLVRB CCR5 GLUD1 GSDMB PIK3R3 SERPINE1 TMEM37 TP63	41 interactors: ADRBK1 ADRBK2 AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B STAT1 STAT3 STAT5A TXK
Entrez ID		5004	1234
HPRD ID		00724	03223
Ensembl ID		ENSG00000229314	ENSG00000160791
Uniprot IDs		P02763	A0A502 P51681 Q38L21
PDB IDs		3KQ0	1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Cell Aging Negative Regulation Of Vascular Wound Healing Epidermal Cell Division Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Ectoderm And Mesoderm Interaction Interaction With Host Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Maintenance Of Mitochondrion Location Regulation Of Body Fluid Levels Positive Regulation Of Behavior Regulation Of Smooth Muscle Cell-matrix Adhesion Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Epidermal Cell Division Chronological Cell Aging Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Regulation Of Vascular Wound Healing Female Genitalia Morphogenesis Cloacal Septation Urinary Bladder Development Regulation Of Behavior Platelet Activation Positive Regulation Of Fibroblast Apoptotic Process Prostatic Bud Formation Cloaca Development Glutamate Catabolic Process Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Keratinocyte Proliferation Negative Regulation Of Plasminogen Activation Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Heme Catabolic Process Polarized Epithelial Cell Differentiation Negative Regulation Of Apoptotic Process Glutamate Biosynthetic Process Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Programmed Cell Death Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Replicative Cell Aging Negative Regulation Of Cell Death Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Fibrinolysis Positive Regulation Of Monocyte Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport	Response To Stress Cell Chemotaxis Defense Response Immune Response Immune System Process Cellular Response To Stimulus Inflammatory Response Cell Migration Cell Motility Response To Stimulus Response To External Stimulus Signaling Locomotion Cell Communication Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signal Transduction Regulation Of Cell Proliferation Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Cellular Metal Ion Homeostasis Cell Activation Cellular Cation Homeostasis Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Natural Killer Cell Chemotaxis Cellular Chemical Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Chemical Homeostasis Response To Cytokine Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Leukocyte Chemotaxis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Granulocyte Chemotaxis Cellular Response To Growth Hormone Stimulus
Tagcloud ?		3t3 a4 adipocytes antioxidants cyclic cytoprotection dismutase endoplasmic ern1 fabp4 glutathione gmp gsh gsta4 h2o2 kinds l1 lowering nitro ormdl3 peroxide reticulum scavenger sod spliced ssr1 superoxide transferase xbp1s	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		3t3 a4 adipocytes antioxidants cyclic cytoprotection dismutase endoplasmic ern1 fabp4 glutathione gmp gsh gsta4 h2o2 kinds l1 lowering nitro ormdl3 peroxide reticulum scavenger sod spliced ssr1 superoxide transferase xbp1s	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?