TYMSOS and KHDRBS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TYMSOS	KHDRBS2
Description		TYMS opposite strand RNA	KH RNA binding domain containing, signal transduction associated 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding SH2 Domain Binding
	Biological Process		Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome
Pathways			PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Diseases
GWAS			Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Chronotype ( 30696823) Corneal astigmatism ( 30306274) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Esophageal adenocarcinoma ( 27527254) Presence of antiphospholipid antibodies ( 27098658) Protein quantitative trait loci ( 18464913)
Interacting Genes		10 interacting genes: APP CCNDBP1 FHL3 KHDRBS2 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 MDFI PRNP	54 interacting genes: AEN BAHD1 BMP7 CATSPER1 CHTOP CIRBP CNNM3 DALRD3 DOCK2 EWSR1 FOXD4L3 GRAP2 GRB2 HBZ HHEX HNRNPA0 HNRNPK HNRNPLL HNRNPR KHDRBS3 LINC01018 LMNTD2 LNX1 MSI2 MTA1 NABP1 NCOA5 NPDC1 PRMT1 PRPF31 PRR3 PSMF1 PTK6 RBFOX2 RBM10 RBM14 RBM3 RBMX RFC3 RPP30 SDCBP SF1 SF3B4 SPG7 SULT1A3 TMEM14B TYK2 TYMSOS YTHDC1 ZFC3H1 ZNF497 ZNF581 ZNF688 ZNF837
Entrez ID		494514	202559
HPRD ID		18668	13775
Ensembl ID			ENSG00000112232
Uniprot IDs			Q5VWX1
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Cellular Response To Copper Ion Molecular Function Activator Activity Response To Copper Ion Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Cellular Response To Amyloid-beta Type 8 Metabotropic Glutamate Receptor Binding Positive Regulation Of Neuron Apoptotic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Protein-folding Chaperone Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium-mediated Signaling Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Type II Interferon Production Cellular Response To Norepinephrine Stimulus Memory Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Type 5 Metabotropic Glutamate Receptor Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Regulation Of Postsynapse Organization	RNA Binding RNA Processing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Binding MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleus Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Splicing Factor Binding Negative Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Regulation Of Metabolic Process Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Ionizing Radiation MRNA Stabilization Negative Regulation Of Biosynthetic Process Precatalytic Spliceosome
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