FAM175B and THAP5

Number of citations of the paper that reports this interaction (PMID 21195082)
7

Data Source:
BioGRID (two hybrid)

		FAM175B	THAP5
Gene Name		family with sequence similarity 175, member B	THAP domain containing 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm BRISC Complex	Nucleus Nucleoplasm
	Molecular Function	Polyubiquitin Binding	Protease Binding DNA Binding Metal Ion Binding
	Biological Process	Cellular Response To Freezing	Cell Cycle Negative Regulation Of Cell Cycle
Pathways
Drugs
Diseases
GWAS			Smoking behavior ( 22006218)
Protein-Protein Interactions		4 interactors: SMURF2 THAP5 UBC USP7	2 interactors: FAM175B SKIL
Entrez ID		23172	168451
HPRD ID		13783	15498
Ensembl ID		ENSG00000165660	ENSG00000177683
Uniprot IDs		Q15018	Q7Z6K1
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Canonical Wnt Signaling Pathway DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Wnt Signaling Pathway Proteolysis Ubiquitin-dependent SMAD Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Maintenance Of DNA Methylation Regulation Of Protein Catabolic Process Catabolic Process Viral Protein Processing Negative Regulation Of Cell Cycle Viral Process Histone Deubiquitination Protein Ubiquitination Cellular Response To Growth Factor Stimulus DNA Repair Response To Growth Factor Notch Receptor Processing Protein Modification By Small Protein Conjugation Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Proteolysis Glycogen Biosynthetic Process Intracellular Transport Of Virus Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus	Cellular Response To Freezing Cellular Response To Cold Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Heterotrimerization Protein Homotrimerization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
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