NUCB1 and PLOD2

Data Source: HiPPIP (Novel)

		NUCB1	PLOD2
Name		nucleobindin 1	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System Membrane Extracellular Exosome	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Rough Endoplasmic Reticulum Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding DNA Binding Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Metal Ion Binding	Iron Ion Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Small GTPase-mediated Signal Transduction	Response To Hypoxia Protein O-linked Glycosylation Peptidyl-lysine Hydroxylation Collagen Fibril Organization Protein Modification Process Hydroxylysine Biosynthetic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Collagen biosynthesis and modifying enzymes
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Ascorbic acid
Diseases		None	Bruck syndrome
GWAS		No GWAS studies recorded	Height ( 31562340 ) Obesity-related traits ( 23251661 ) Squamous cell lung carcinoma ( 28604730 ) Zinc levels ( 26025379 )
Novel Interactors		1 novel interactors: PLOD2	6 novel interactors: CENPF CLSTN2 LITAF LYPLA1 NUCB1 WWTR1
Interacting Genes		18 interacting genes: DYRK1A GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAZ HIVEP1 HOXA1 MYC NDN PTGS1 PTGS2 RBL1 REL SET SIRPA XPO1	1 interacting genes: LINC01554
Entrez ID		4924	5352
HPRD ID		03205	03519
Ensembl ID		ENSG00000104805	ENSG00000152952
Uniprot IDs		A8K7Q1 Q02818	A0A994J6S5 O00469
PDB IDs		1SNL	Not available
GO Terms Enriched among Interactors		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Binding Mu-type Opioid Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway GTP Binding Cyclooxygenase Pathway Prostaglandin-endoperoxide Synthase Activity Adenylate Cyclase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion By Cell Regulation Of Insulin Secretion Negative Regulation Of Secretion Positive Regulation Of Metabolic Process Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion G Protein Activity Negative Regulation Of Protein Secretion Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Negative Regulation Of Transport Dioxygenase Activity Regulation Of Protein Transport Cell Body Negative Regulation Of Cell Communication Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Interferon-beta Production Prostaglandin Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Regulation Of Protein Secretion Prostanoid Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Macromolecule Biosynthetic Process G Protein-coupled Dopamine Receptor Signaling Pathway Protein-DNA Complex Disassembly Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Transport Regulation Of Secretion By Cell Response To Prostaglandin E	None