NELFB and KHDRBS3

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		NELFB	KHDRBS3
Gene Name		negative elongation factor complex member B	KH domain containing, RNA binding, signal transduction associated 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm NELF Complex	Nucleus Nucleoplasm
	Molecular Function	Protein Binding	RNA Binding Protein Binding SH3 Domain Binding Poly(A) RNA Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Spermatogenesis
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: BRCA1 CEBPE DENR ESR1 FOS HSPA9 JUN KHDRBS3 MAPK6 MGST1 NELFA NELFE	30 interactors: BAHD1 CACNA1A CCDC33 DMRT3 FUS HNRNPC HNRNPK INPP5D KHDRBS1 KHDRBS2 LNX1 MARK4 NCOA5 NELFB NUDT18 PRMT1 PRPF31 PSMF1 PTBP2 RBBP6 RBM7 RBMX RBMY1A1 SGSM2 SIAH1 SNRPC SRSF9 U2AF2 YTHDC1 ZNF408
Entrez ID		25920	10656
HPRD ID		10845	10007
Ensembl ID		ENSG00000188986	ENSG00000131773
Uniprot IDs		Q8WX92	O75525
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Transcription Response To Lipid Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Viral Transcription Biosynthetic Process Positive Regulation Of Viral Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Response To Lipopolysaccharide Negative Regulation Of DNA-templated Transcription, Elongation Response To Molecule Of Bacterial Origin Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Regulation Of Viral Process Response To Bacterium Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription Elongation From RNA Polymerase II Promoter MAPK Cascade Nitrogen Compound Metabolic Process Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription, DNA-templated Cellular Response To Calcium Ion Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of RNA Biosynthetic Process Response To Other Organism Toll-like Receptor 5 Signaling Pathway Signal Transduction By Phosphorylation RNA Metabolic Process Toll-like Receptor 10 Signaling Pathway Regulation Of RNA Metabolic Process SMAD Protein Signal Transduction Response To Biotic Stimulus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Nucleobase-containing Compound Metabolic Process Toll-like Receptor 9 Signaling Pathway Transcription Elongation From RNA Polymerase II Promoter	MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Metabolic Process RNA Processing Gene Expression RNA Metabolic Process Negative Regulation Of RNA Splicing Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing MRNA Splice Site Selection Spliceosomal Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Assembly Regulation Of MRNA Processing Metabolic Process Regulation Of Metabolic Process Ribonucleoprotein Complex Biogenesis Regulation Of Gene Expression Transcription, DNA-templated Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Component Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Termination Of RNA Polymerase II Transcription Cerebellar Molecular Layer Development DGDP Catabolic Process DADP Catabolic Process GDP Catabolic Process Adult Walking Behavior Cellular Process Cellular Macromolecule Biosynthetic Process Ventral Spinal Cord Development Transmission Of Nerve Impulse Macromolecule Biosynthetic Process Vestibular Nucleus Development
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