DNAJA3 and FXR1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		DNAJA3	FXR1
Description		DnaJ heat shock protein family (Hsp40) member A3	FMR1 autosomal homolog 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Actin Filament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Neuromuscular Junction Mitochondrial Nucleoid Synapse Postsynaptic Membrane	Nucleus Nuclear Envelope Nucleolus Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Axon Dendrite Ribonucleoprotein Granule Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Costamere Dendritic Spine Intracellular Membraneless Organelle Synapse Perinuclear Region Of Cytoplasm Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Type II Interferon Receptor Binding Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding Hsp70 Protein Binding GTPase Regulator Activity Heat Shock Protein Binding Protein-containing Complex Binding Metal Ion Binding NF-kappaB Binding Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding IkappaB Kinase Complex Binding DNA-binding Transcription Factor Binding	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding RNA Strand Annealing Activity MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Translation Regulator Activity Protein Heterodimerization Activity Molecular Condensate Scaffold Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Immune System Process Mitochondrial DNA Replication Protein Folding Apoptotic Process Activation-induced Cell Death Of T Cells Response To Stress Mitochondrion Organization Small GTPase-mediated Signal Transduction Neuromuscular Junction Development Negative Regulation Of Cell Population Proliferation Response To Heat Positive Regulation Of Protein Ubiquitination T Cell Differentiation In Thymus Response To Type II Interferon Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein Stabilization Negative Regulation Of Type II Interferon-mediated Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Cellular Senescence	Cytoplasmic Translational Initiation Regulation Of Translation Apoptotic Process Spermatogenesis Spermatid Development Muscle Organ Development Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Dentate Gyrus Development Cell Differentiation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rho Protein Signal Transduction Regulation Of MRNA Stability Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Translation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development Negative Regulation Of Inflammatory Response Regulation Of Neurogenesis MRNA Transport Nuclear Pore Complex Assembly Nuclear Pore Localization Regulation Of Synaptic Transmission, Glutamatergic Skeletal Muscle Organ Development Muscle Structure Development MRNA Destabilization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Membraneless Organelle Assembly Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of MRNA Catabolic Process Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways			Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 32888494) Schizophrenia ( 28991256) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Bipolar disorder and eating disorder ( 26433762) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eating disorder in bipolar disorder ( 26433762) Mastocytosis ( 32752121) Metabolite levels ( 23823483) Schizophrenia ( 19571811 25056061 29483656 30285260)
Interacting Genes		47 interacting genes: ATOSB ATXN1 BRCA1 CACNA1C CARM1 CATSPERT CIDEB COIL CYSRT1 FAM131C FBXO7 FOSL2 FRMD6 FXR1 GCC1 GFI1B GRB2 HSPA1A HSPA8 IFNGR2 INPP5J JAK2 KDM1A KRAS LAMTOR5 MCPH1 MET MYO15B NFKBIA NFKBIB NOC4L NTRK1 OSGIN1 PRMT6 PTEN RAD51 RASA1 RELA RNF34 SHANK3 SMAD9 SMARCB1 STK16 TCF19 USP7 VHL ZBTB22	254 interacting genes: ABI1 ACLY ACOT7 ACTB ACTN1 ACTN2 ADAMTSL4 AHCY ALAS1 ANKRD40 ANKS3 AP1M1 APC2 ARHGAP22 ARHGEF7 ATN1 AXIN1 AXIN2 BCKDK BEND5 BHLHE40 BICD1 BLK BLTP3B BTBD2 BTBD6 BYSL C1orf35 CA10 CACTIN-AS1 CALCOCO1 CAMK2A CAMK2B CAMK2G CAPN3 CBS CBX8 CCAR2 CCBE1 CCDC187 CCDC92 CCN3 CDC7 CDKL3 CDR2 CDYL CEP126 CEP72 CEP89 CHRD CIRSR COIL CORO1A CORO1B CORO6 CPLANE1 CRMP1 CSNK2A1 CSNK2B CWF19L2 CYFIP2 DCTD DCTN1 DCTN2 DCTPP1 DEAF1 DHX15 DNAJA3 DNM2 ECH1 ECHS1 ECM1 EDC4 EFEMP2 EGFL7 EIF3A ELOA ENO1 ERCC6 ERG28 ERVFRD-1 ESCO2 EVL FAM161A FAM90A1 FBLN1 FLAD1 FLNB FMR1 FTH1 FXR2 GBP2 GFAP GLYR1 GOLGA2 GOLGA3 GPSM2 GRIA2 GRIP1 GRIP2 GRIPAP1 HIVEP1 HLA-DRB5 HMG20A HNRNPH2 HNRNPM HNRNPUL1 HOMER2 HOMER3 HSPB1 IK IMPDH2 INA JAKMIP1 KAZN KCNN1 KCTD1 KCTD13 KEAP1 KHDRBS1 KHDRBS3 KIAA1549L KIF17 KIF9 KRT18 LAP3 LNX1 LRIF1 LRSAM1 LUC7L2 LZTS2 MAD1L1 MAGED1 MAGOH MAGOHB MAPK7 MAPK8IP3 MAPKBP1 MBIP MCRS1 MFAP1 MLLT1 MOAP1 MSANTD3 MTUS2 MVP MX1 MYH10 MYH9 MYO5B N4BP3 NBPF15 NECAB2 NECAB3 NEFL NEIL3 NKD2 NME1 NME1-NME2 NME3 PAFAH1B3 PAICS PCCB PCED1A PDE9A PHC1P1 PHC2 PHLDB1 PKM PML PNMA1 PPHLN1 PPP1R12C PRAM1 PRKCSH PRPF31 PRR13 PRSS23 PSMC3 PSMC5 PSME1 PSME3 PYCR1 PYCR2 PYCR3 RABAC1 RALYL RBM26 RBM45 RPIA RUSC2 SAFB2 SAMD1 SCMH1 SEPTIN2 SERTAD1 SF3B2 SFPQ SH3GL2 SH3GLB2 SHANK1 SHARPIN SLC48A1 SLIT1 SMN1 SNURF SORBS3 SOX5 SPECC1 SPRY1 SPRY2 SRPK2 SSNA1 STK16 STUB1 SUFU SYT6 TACC2 TASOR2 TBC1D22B TCEA2 TDRD7 TLE5 TMPO TNFAIP1 TRAF2 TRAP1 TRIM3 TRIOBP TRPM1 TSN TTLL5 TUBB UBAP2L UBP1 USP7 UXS1 VIM VPS51 VWF WASH6P WEE2-AS1 WRNIP1 YAP1 YES1 YY1AP1 ZFTRAF1 ZMAT2 ZNF212 ZNF417 ZNF423 ZNF438 ZNF71 ZNF821
Entrez ID		9093	8087
HPRD ID		09758	02892
Ensembl ID		ENSG00000103423	ENSG00000114416
Uniprot IDs		B3KM81 Q53G26 Q59E88 Q96EY1	E7EU85 P51114
PDB IDs		2CTT 2DN9 6IWS 7X89	2CPQ 3KUF 3O8V
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Regulation Of Cell Development Regulation Of Cell Differentiation Nucleoplasm Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Histone H3R2 Methyltransferase Activity Positive Regulation Of Nervous System Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Apoptotic Process Regulation Of Gene Expression Positive Regulation Of Cell Differentiation Histone Arginine N-methyltransferase Activity Regulation Of Nervous System Development Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neurogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Primary Metabolic Process	Identical Protein Binding Cytosol Cytoplasm Cytoskeleton Protein Binding Regulation Of Proteolysis Cytoskeleton Organization Postsynaptic Cytoskeleton Organization Centrosome Nucleoplasm Protein Domain Specific Binding Regulation Of Proteasomal Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Pyrroline-5-carboxylate Reductase Activity Nucleus Neuron Projection Actin Filament Organelle Organization Synapse Positive Regulation Of Proteolysis Mitotic Spindle Pole RNA Splicing, Via Transesterification Reactions Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Protein Metabolic Process L-proline Biosynthetic Process RNA Splicing PcG Protein Complex MRNA Processing Stress Fiber MRNA Splicing, Via Spliceosome Microtubule Cytoskeleton Organization Supramolecular Fiber Organization Nervous System Development Postsynaptic Actin Cytoskeleton Organization Protein Homodimerization Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Protection Cell Cortex U2-type Precatalytic Spliceosome Bud Elongation Involved In Lung Branching Glutamate Receptor Signaling Pathway Structural Constituent Of Cytoskeleton Postsynaptic Density Microtubule Binding Crotonyl-CoA Hydratase Activity Uropod Organization Protein Kinase Binding RNA Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process GTP Biosynthetic Process
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