DNAJA3 and MET

Number of citations of the paper that reports this interaction (PubMedID 35384245)
105

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)
HPRD (two hybrid)

		DNAJA3	MET
Description		DnaJ heat shock protein family (Hsp40) member A3	MET proto-oncogene, receptor tyrosine kinase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Actin Filament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Neuromuscular Junction Mitochondrial Nucleoid Synapse Postsynaptic Membrane	Extracellular Region Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Receptor Complex Postsynapse
	Molecular Function	Signaling Receptor Binding Type II Interferon Receptor Binding Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding Hsp70 Protein Binding GTPase Regulator Activity Heat Shock Protein Binding Protein-containing Complex Binding Metal Ion Binding NF-kappaB Binding Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding IkappaB Kinase Complex Binding DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Hepatocyte Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Semaphorin Receptor Activity Protein Phosphatase Binding Identical Protein Binding Molecular Function Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Immune System Process Mitochondrial DNA Replication Protein Folding Apoptotic Process Activation-induced Cell Death Of T Cells Response To Stress Mitochondrion Organization Small GTPase-mediated Signal Transduction Neuromuscular Junction Development Negative Regulation Of Cell Population Proliferation Response To Heat Positive Regulation Of Protein Ubiquitination T Cell Differentiation In Thymus Response To Type II Interferon Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein Stabilization Negative Regulation Of Type II Interferon-mediated Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Cellular Senescence	Endothelial Cell Morphogenesis Liver Development Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Autophagy Neuron Differentiation Pancreas Development Positive Regulation Of Microtubule Polymerization Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Cell Development Animal Organ Development Branching Morphogenesis Of An Epithelial Tube Positive Chemotaxis Negative Regulation Of Stress Fiber Assembly Excitatory Postsynaptic Potential Establishment Of Skin Barrier Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Semaphorin-plexin Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Endothelial Cell Chemotaxis
Pathways			PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D mediated inhibition of cell attachment and migration RAF/MAP kinase cascade MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 MECP2 regulates neuronal receptors and channels Drug-mediated inhibition of MET activation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs			Sunitinib K-252a SGX-523 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol AMG-208 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Crizotinib Cabozantinib Capmatinib Tivozanib Fostamatinib Tivantinib Brigatinib Amuvatinib Tepotinib Amivantamab
Diseases			Cholangiocarcinoma Gastric cancer Renal cell carcinoma
GWAS		Erectile dysfunction ( 30583798) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 32888494) Schizophrenia ( 28991256) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Gamma glutamyl transferase levels ( 29403010 33339817) HDL cholesterol levels ( 28334899) Heel bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 28017375) Lung function (FEV1/FVC) ( 30804560) Medication use (beta blocking agents) ( 31015401) Multiple sclerosis (severity) ( 19010793) PR segment duration ( 24850809) Pulse pressure ( 30578418) Resting heart rate ( 27798624 29769521) Triglyceride levels ( 28334899) Triglycerides ( 24097068) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		47 interacting genes: ATOSB ATXN1 BRCA1 CACNA1C CARM1 CATSPERT CIDEB COIL CYSRT1 FAM131C FBXO7 FOSL2 FRMD6 FXR1 GCC1 GFI1B GRB2 HSPA1A HSPA8 IFNGR2 INPP5J JAK2 KDM1A KRAS LAMTOR5 MCPH1 MET MYO15B NFKBIA NFKBIB NOC4L NTRK1 OSGIN1 PRMT6 PTEN RAD51 RASA1 RELA RNF34 SHANK3 SMAD9 SMARCB1 STK16 TCF19 USP7 VHL ZBTB22	112 interacting genes: ABL2 BAG1 BCAR3 BLK BTK CASP3 CBL CCND2 CD44 CDK4 CDK6 CDKN2B CNR1 CRK CTNNB1 CTTN DAPK3 DCN DNAJA3 EGFR EPHA2 ERBB2 FAS FES FGFR4 FGR FZR1 GAB1 GLIS2 GLMN GRB14 GRB2 GRB7 HCK HGF HGS HSH2D INPP5D INPPL1 ITGB1 ITGB4 ITK KDELR2 LATS2 LCK LYN MAP2K3 MAP2K5 MATK MUC20 MYC NCK1 NCK2 NF2 PCBD2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PLXNB1 PTK6 PTPN11 PTPRB PTPRJ RAF1 RANBP10 RANBP9 RASA1 RASSF1 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA2 SMC1A SNAPIN SNX2 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SPSB1 SRC STAP1 STAT3 STK11 SYK TEC TERT TNS1 TNS2 TNS3 TNS4 TP53 TXK VAV1 VAV2 VAV3 YES1 ZAP70
Entrez ID		9093	4233
HPRD ID		09758	01280
Ensembl ID		ENSG00000103423	ENSG00000105976
Uniprot IDs		B3KM81 Q53G26 Q59E88 Q96EY1	B4DLF5 E6Y365 P08581
PDB IDs		2CTT 2DN9 6IWS 7X89	1FYR 1R0P 1R1W 1SHY 1SSL 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 2WKM 3A4P 3BUX 3C1X 3CCN 3CD8 3CE3 3CTH 3CTJ 3DKC 3DKF 3DKG 3EFJ 3EFK 3F66 3F82 3I5N 3L8V 3LQ8 3Q6U 3Q6W 3QTI 3R7O 3RHK 3U6H 3U6I 3VW8 3ZBX 3ZC5 3ZCL 3ZXZ 3ZZE 4AOI 4AP7 4DEG 4DEH 4DEI 4EEV 4GG5 4GG7 4IWD 4K3J 4KNB 4MXC 4O3T 4O3U 4R1V 4R1Y 4XMO 4XYF 5DG5 5EOB 5EYC 5EYD 5HLW 5HNI 5HO6 5HOA 5HOR 5HTI 5LSP 5T3Q 5UAB 5UAD 5YA5 6GCU 6I04 6SD9 6SDC 6SDD 6SDE 6UBW 6WVZ 7B3Q 7B3T 7B3V 7B3W 7B3Z 7B40 7B41 7B42 7B43 7B44 7MO7 7MO8 7MO9 7MOA 7MOB 7V3R 7V3S 7Y4T 7Y4U 8AN8 8ANS 8AU3 8AU5 8AW1 8GVJ 8K78 8OUU 8OUV 8OV7 8OVZ 8OW3 8OWG 9C1R 9IVB
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Regulation Of Cell Development Regulation Of Cell Differentiation Nucleoplasm Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Histone H3R2 Methyltransferase Activity Positive Regulation Of Nervous System Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Apoptotic Process Regulation Of Gene Expression Positive Regulation Of Cell Differentiation Histone Arginine N-methyltransferase Activity Regulation Of Nervous System Development Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neurogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Primary Metabolic Process	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Adhesion Cytosol ERBB Signaling Pathway Immune Response-activating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Cell Activation Peptidyl-tyrosine Phosphorylation Leukocyte Activation Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Negative Regulation Of Signal Transduction Protein Kinase Activity Lymphocyte Activation Activation Of Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Immune System Process Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Immune System Process Fc Receptor Signaling Pathway Regulation Of Lymphocyte Activation Kinase Activity Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Regulation Of Cell-cell Adhesion Regulation Of MAPK Cascade T Cell Activation
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