NPPC and NPR3

Number of citations: 0 (PubMedID 1672777)
Data Source: BioGRID (pull down), HPRD (in vitro)

		NPPC	NPR3
Name		natriuretic peptide C	natriuretic peptide receptor 3
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Protein-containing Complex	Plasma Membrane Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding	Protein Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Chloride Ion Binding Peptide Binding Hormone Binding Protein Homodimerization Activity Receptor Decoy Activity
	Biological Process	Ossification Angiogenesis Ovarian Follicle Development Cumulus Cell Differentiation Response To Hypoxia Blood Vessel Remodeling Response To Ischemia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Protein Folding Intracellular Calcium Ion Homeostasis Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Wounding Post-embryonic Development Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Negative Regulation Of Collagen Biosynthetic Process Gastric Emptying Response To Decreased Oxygen Levels Regulation Of Multicellular Organism Growth Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Osteoblast Differentiation Animal Organ Development Oocyte Development Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Chromosome Organization Meiotic Cell Cycle Negative Regulation Of Meiotic Cell Cycle C-di-GMP Signaling Multicellular Organismal Locomotion Response To Oxygen-glucose Deprivation Blood Vessel Diameter Maintenance Bone Growth Negative Regulation Of Oocyte Maturation Meiotic Cell Cycle Process Involved In Oocyte Maturation Cellular Response To Glycoprotein Negative Regulation Of DNA Biosynthetic Process	Skeletal System Development Angiogenesis Blood Vessel Remodeling Osteoclast Proliferation Response To Ischemia CGMP Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Relaxation Of Smooth Muscle
Pathways		Physiological factors	None
Drugs		None	Nesiritide
GWAS		Height ( 18391951 19570815 20881960 25282103 25429064 ) Hip circumference adjusted for BMI ( 34021172 ) Refractive error ( 32231278 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 )	Appendicular lean mass ( 33097823 ) Blood pressure ( 21572416 21909110 24954895 ) Diastolic blood pressure ( 27618452 27841878 26390057 28739976 21909115 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Height ( 31562340 28552196 28270201 19570815 23563607 19343178 20881960 25282103 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Hypertension ( 31879980 21909115 ) Mean arterial pressure ( 26390057 30487518 29403010 ) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Ovarian reserve ( 22116950 ) Pulse pressure ( 30578418 28739976 27841878 ) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401 ) Systolic blood pressure ( 30578418 21909115 27618447 29403010 28739976 28135244 27841878 26390057 27618452 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		None recorded	3 novel interactors: NFKBIE NSD1 SLC30A9
Interacting Genes		4 interacting genes: MME NPR1 NPR2 NPR3	3 interacting genes: NPPA NPPB NPPC
Entrez ID		4880	4883
HPRD ID		08975	00167
Ensembl ID		ENSG00000163273	ENSG00000113389
Uniprot IDs		E5LCN7 P23582	A8K4A5 C9JK69 P17342 Q60I31
PDB IDs		1JDP	1JDN 1JDP 1YK0 1YK1
GO Terms Enriched among Interactors		Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Ribose Phosphate Biosynthetic Process Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process Nucleotide Biosynthetic Process Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine-containing Compound Biosynthetic Process Peptide Binding Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process G Protein-coupled Peptide Receptor Activity Blood Circulation Purine Nucleotide Metabolic Process Blood Vessel Remodeling Small Molecule Metabolic Process System Process Nucleotide Metabolic Process Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Tissue Remodeling Neuropeptide Processing ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Renal System Process Carbohydrate Derivative Metabolic Process Oligopeptidase Activity Creatinine Metabolic Process Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Lyase Activity Nucleobase-containing Compound Biosynthetic Process Regulation Of Biological Quality	Hormone Receptor Binding Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Cyclic Purine Nucleotide Metabolic Process Positive Regulation Of CGMP-mediated Signaling Hormone Activity Regulation Of CGMP-mediated Signaling Purine Ribonucleotide Biosynthetic Process Blood Vessel Diameter Maintenance Cardiac Conduction System Development Regulation Of Tube Size Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Protein Folding Nucleotide Biosynthetic Process Purine-containing Compound Biosynthetic Process Vascular Process In Circulatory System Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Regulation Of Vascular Permeability Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Negative Regulation Of Blood Pressure Nuclear Receptor Binding Circulatory System Process Vasodilation Purine Nucleotide Metabolic Process Cardiac Muscle Tissue Development Signaling Receptor Binding Nucleotide Metabolic Process Negative Regulation Of Collecting Lymphatic Vessel Constriction Diuretic Hormone Activity Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process Neuropeptide Signaling Pathway Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Neuropeptide Receptor Binding Response To 3-methylcholanthrene Cumulus Cell Differentiation C-di-GMP Signaling Multicellular Organismal Locomotion Gastric Emptying Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Nucleobase-containing Small Molecule Metabolic Process