NPPC

Name	natriuretic peptide C
Structure
Interactors	4 interactors: MME NPR1 NPR2 NPR3
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Protein-containing Complex
	Molecular Function	Signaling Receptor Binding Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding
	Biological Process	Ossification Angiogenesis Ovarian Follicle Development Cumulus Cell Differentiation Response To Hypoxia Blood Vessel Remodeling Response To Ischemia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Protein Folding Intracellular Calcium Ion Homeostasis Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Wounding Post-embryonic Development Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Negative Regulation Of Collagen Biosynthetic Process Gastric Emptying Response To Decreased Oxygen Levels Regulation Of Multicellular Organism Growth Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Osteoblast Differentiation Animal Organ Development Oocyte Development Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Chromosome Organization Meiotic Cell Cycle Negative Regulation Of Meiotic Cell Cycle C-di-GMP Signaling Multicellular Organismal Locomotion Response To Oxygen-glucose Deprivation Blood Vessel Diameter Maintenance Bone Growth Negative Regulation Of Oocyte Maturation Meiotic Cell Cycle Process Involved In Oocyte Maturation Cellular Response To Glycoprotein Negative Regulation Of DNA Biosynthetic Process
Pathways	Physiological factors
GWAS	Height ( 18391951 19570815 20881960 25282103 25429064 ) Hip circumference adjusted for BMI ( 34021172 ) Refractive error ( 32231278 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 )
Entrez ID	4880
HPRD ID	08975
Ensembl ID	ENSG00000163273
Uniprot IDs	E5LCN7 P23582
PDB IDs	1JDP
GO Terms Enriched among Interactors ?	Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Ribose Phosphate Biosynthetic Process Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process Nucleotide Biosynthetic Process Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine-containing Compound Biosynthetic Process Peptide Binding Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process G Protein-coupled Peptide Receptor Activity Blood Circulation Purine Nucleotide Metabolic Process Blood Vessel Remodeling Small Molecule Metabolic Process System Process Nucleotide Metabolic Process Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Tissue Remodeling Neuropeptide Processing ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Renal System Process Carbohydrate Derivative Metabolic Process Oligopeptidase Activity Creatinine Metabolic Process Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Lyase Activity Nucleobase-containing Compound Biosynthetic Process Regulation Of Biological Quality