NPPC and NPR2

Number of citations of the paper that reports this interaction (PMID 1672777)
65

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		NPPC	NPR2
Gene Name		natriuretic peptide C	natriuretic peptide receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Secretory Granule	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Hormone Activity Protein Homodimerization Activity Peptide Hormone Receptor Binding	Guanylate Cyclase Activity Protein Kinase Activity Receptor Activity Transmembrane Signaling Receptor Activity ATP Binding GTP Binding Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding
	Biological Process	Ossification Response To Hypoxia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Proliferation Post-embryonic Development Regulation Of CAMP Metabolic Process Regulation Of CGMP Metabolic Process Positive Regulation Of CGMP Biosynthetic Process Regulation Of Multicellular Organism Growth Response To Drug Single Organism Reproductive Process Response To Ethanol Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Vasodilation Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Vessel Size Negative Regulation Of DNA Metabolic Process Negative Regulation Of Meiotic Cell Cycle Negative Regulation Of Oocyte Maturation	Ossification CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Blood Pressure Intracellular Signal Transduction Single Organism Reproductive Process Negative Regulation Of Meiotic Cell Cycle Bone Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Oocyte Maturation
Pathways
Drugs			Erythrityl Tetranitrate Nesiritide
Diseases
GWAS		Height ( 20881960 19570815 18391951)
Protein-Protein Interactions		4 interactors: MME NPR1 NPR2 NPR3	3 interactors: NPPA NPPB NPPC
Entrez ID		4880	4882
HPRD ID		08975	00166
Ensembl ID			ENSG00000159899
Uniprot IDs		E5LCN7 P23582	P20594
PDB IDs		1JDP
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Pressure Blood Circulation Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Cellular Response To UV-A Negative Regulation Of Oocyte Maturation Negative Regulation Of Oocyte Development Osteoclast Proliferation Creatinine Metabolic Process Ribonucleotide Metabolic Process Response To UV-A Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Pancreatic Juice Secretion Cellular Response To UV-B Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Angiotensin Maturation Intracellular Signal Transduction Regulation Of Angiotensin Metabolic Process Positive Regulation Of Renal Sodium Excretion Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Response To UV-B Replicative Senescence Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of Nitric-oxide Synthase Activity Beta-amyloid Metabolic Process Positive Regulation Of CGMP Metabolic Process Skeletal System Development Nucleotide Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Small Molecule Metabolic Process Regulation Of Renal Sodium Excretion Negative Regulation Of Adenylate Cyclase Activity Regulation Of CGMP Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Lyase Activity Regulation Of Osteoblast Proliferation	Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Cyclic Nucleotide Biosynthetic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Cyclic Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Blood Circulation Ribose Phosphate Metabolic Process Regulation Of Vasodilation Nucleotide Metabolic Process Regulation Of Growth Nucleobase-containing Small Molecule Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Organophosphate Metabolic Process Negative Regulation Of Cell Growth Regulation Of Blood Pressure Growth Plate Cartilage Chondrocyte Proliferation Negative Regulation Of Growth Negative Regulation Of Oocyte Maturation Response To Hypoxia Regulation Of Generation Of L-type Calcium Current Positive Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Oocyte Development Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Cardiac Muscle Contraction Growth Plate Cartilage Chondrocyte Differentiation Small Molecule Metabolic Process Regulation Of Delayed Rectifier Potassium Channel Activity Response To Muscle Stretch Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Renal Sodium Excretion Phosphate-containing Compound Metabolic Process Positive Regulation Of Urine Volume Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of CGMP Biosynthetic Process Cardiac Muscle Hypertrophy In Response To Stress Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of CGMP Metabolic Process Growth Plate Cartilage Development
Tagcloud ?			cat1 clearly deltanpr2 deltatsc2 discovered displayed feedback homeostasis isolating isp5 loop mislocalization negatively nutrient permease phenocopy phenotypes pombe rapamycin regulators schizosaccharomyces screen sensing supersensitivity terms tor tor2 torc1 tsc2
Tagcloud (Difference) ?			cat1 clearly deltanpr2 deltatsc2 discovered displayed feedback homeostasis isolating isp5 loop mislocalization negatively nutrient permease phenocopy phenotypes pombe rapamycin regulators schizosaccharomyces screen sensing supersensitivity terms tor tor2 torc1 tsc2
Tagcloud (Intersection) ?