NPPC and NPR2

Number of citations: 0 (PubMedID 1672777)
Data Source: BioGRID (pull down), HPRD (in vivo)

		NPPC	NPR2
Name		natriuretic peptide C	natriuretic peptide receptor 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Protein-containing Complex	Nucleus Cytoplasm Plasma Membrane Cilium Membrane Neuron Projection Synapse
	Molecular Function	Signaling Receptor Binding Hormone Activity Guanylate Cyclase Activator Activity Hormone Receptor Binding	Nucleotide Binding Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding
	Biological Process	Ossification Angiogenesis Ovarian Follicle Development Cumulus Cell Differentiation Response To Hypoxia Blood Vessel Remodeling Response To Ischemia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Protein Folding Intracellular Calcium Ion Homeostasis Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Wounding Post-embryonic Development Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Negative Regulation Of Collagen Biosynthetic Process Gastric Emptying Response To Decreased Oxygen Levels Regulation Of Multicellular Organism Growth Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Osteoblast Differentiation Animal Organ Development Oocyte Development Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Chromosome Organization Meiotic Cell Cycle Negative Regulation Of Meiotic Cell Cycle C-di-GMP Signaling Multicellular Organismal Locomotion Response To Oxygen-glucose Deprivation Blood Vessel Diameter Maintenance Bone Growth Negative Regulation Of Oocyte Maturation Meiotic Cell Cycle Process Involved In Oocyte Maturation Cellular Response To Glycoprotein Negative Regulation Of DNA Biosynthetic Process	MAPK Cascade Ossification Ovarian Follicle Development Cumulus Cell Differentiation Blood Vessel Development Vasculogenesis Lymph Vessel Development Endochondral Ossification Startle Response Blood Vessel Remodeling Chondrocyte Differentiation Growth Plate Cartilage Development CGMP Biosynthetic Process Vacuole Organization Receptor Guanylyl Cyclase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Chemical Synaptic Transmission Germ Cell Development Spermatogenesis Single Fertilization Axonogenesis Sensory Perception Of Sound Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Response To Wounding Response To Hormone Neuronal Action Potential Vestibulocochlear Nerve Development Vestibulocochlear Nerve Maturation Nerve Development Female Genitalia Development Response To Luteinizing Hormone Limb Morphogenesis Genitalia Morphogenesis Multicellular Organism Growth Gastric Emptying Intracellular Signal Transduction Chondrocyte Proliferation Post-anal Tail Morphogenesis CGMP Metabolic Process Digestive Tract Morphogenesis Digestive Tract Development Oocyte Development Collateral Sprouting Smooth Muscle Tissue Development White Fat Cell Differentiation Cartilage Development Chromosome Organization Meiotic Cell Cycle Neuron Apoptotic Process Negative Regulation Of Meiotic Cell Cycle Limb Development Bone Development Axonogenesis Involved In Innervation Activation Of Meiosis Involved In Egg Activation Vascular Wound Healing C-di-GMP Signaling Cellular Response To CGMP Response To Fibroblast Growth Factor Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Execution Phase Of Apoptosis Bone Growth Negative Regulation Of Oocyte Maturation Cellular Response To Peptide Response To Salt Meiotic Cell Cycle Process Involved In Oocyte Maturation
Pathways		Physiological factors	Physiological factors
Drugs		None	Erythrityl tetranitrate Nesiritide Vosoritide
Diseases		None	Acromesomelic dysplasia, Maroteaux type
GWAS		Height ( 18391951 19570815 20881960 25282103 25429064 ) Hip circumference adjusted for BMI ( 34021172 ) Refractive error ( 32231278 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 )	Brain morphology (MOSTest) ( 32665545 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 )
Novel Interactors		None recorded	1 novel interactors: DNAI1
Interacting Genes		4 interacting genes: MME NPR1 NPR2 NPR3	3 interacting genes: NPPA NPPB NPPC
Entrez ID		4880	4882
HPRD ID		08975	00166
Ensembl ID		ENSG00000163273	ENSG00000159899
Uniprot IDs		E5LCN7 P23582	P20594
PDB IDs		1JDP	Not available
GO Terms Enriched among Interactors		Natriuretic Peptide Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Purine Ribonucleotide Biosynthetic Process Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Ribose Phosphate Biosynthetic Process Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process Nucleotide Biosynthetic Process Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine-containing Compound Biosynthetic Process Peptide Binding Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process G Protein-coupled Peptide Receptor Activity Blood Circulation Purine Nucleotide Metabolic Process Blood Vessel Remodeling Small Molecule Metabolic Process System Process Nucleotide Metabolic Process Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Tissue Remodeling Neuropeptide Processing ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Renal System Process Carbohydrate Derivative Metabolic Process Oligopeptidase Activity Creatinine Metabolic Process Cumulus Cell Differentiation C-di-GMP Signaling Activation Of Meiosis Involved In Egg Activation Gastric Emptying Lyase Activity Nucleobase-containing Compound Biosynthetic Process Regulation Of Biological Quality	Hormone Receptor Binding Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Cyclic Purine Nucleotide Metabolic Process Positive Regulation Of CGMP-mediated Signaling Hormone Activity Purine Ribonucleotide Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Blood Vessel Diameter Maintenance Ribose Phosphate Biosynthetic Process Regulation Of Tube Size Regulation Of CGMP-mediated Signaling Purine Nucleotide Biosynthetic Process Cardiac Conduction System Development Nucleotide Biosynthetic Process Protein Folding Purine-containing Compound Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Vascular Process In Circulatory System Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Circulatory System Process Purine Nucleotide Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Blood Pressure Signaling Receptor Binding Nucleotide Metabolic Process Vasodilation Carbohydrate Derivative Biosynthetic Process Cardiac Muscle Tissue Development Purine-containing Compound Metabolic Process Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Growth Cell Surface Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of Collecting Lymphatic Vessel Constriction Extracellular Region Diuretic Hormone Activity Protein-containing Complex Striated Muscle Tissue Development Carbohydrate Derivative Metabolic Process Neuropeptide Receptor Binding