TNFRSF25 and NCOA7

		TNFRSF25	NCOA7
Description		TNF receptor superfamily member 25	nuclear receptor coactivator 7
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GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane	Nucleus
	Molecular Function	Tumor Necrosis Factor Receptor Activity Signaling Receptor Activity	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cellular Response To Oxidative Stress
Pathways		TNFs bind their physiological receptors
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 35210625 23872634) Endometrial cancer ( 27135401 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Heel bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip index ( 34021172) Immature fraction of reticulocytes ( 32888494) Left–right brain asymmetry ( 33723403) Menarche (age at onset) ( 25231870) Migraine ( 27322543) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 33838163) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30578418 30224653) Urate levels ( 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: BAG4 DAP3 DYRK1A MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2	4 interacting genes: AHR ARNT ESR1 ESR2
Entrez ID		8718	135112
HPRD ID		04532	14814
Ensembl ID		ENSG00000215788	ENSG00000111912
Uniprot IDs		Q93038	B3KXK4 H0Y5F6 Q8NI08
PDB IDs		5YGP 5YGS	7OBP 8AR6 8AR9
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Superfamily Complex Non-canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Binding Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Tumor Necrosis Factor Negative Regulation Of MRNA Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Response To Tumor Necrosis Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Intracellular Signaling Cassette Regulation Of Apoptotic Process Receptor Complex Regulation Of Programmed Cell Death Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Histone H3T45 Kinase Activity Diuretic Hormone Activity Positive Regulation Of Protein Phosphorylation Response To Epidermal Growth Factor Fructose Import Across Plasma Membrane Positive Regulation Of Signal Transduction TORC2 Complex Disassembly Negative Regulation Of MRNA Modification Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Cytosine Metabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly	Nuclear Receptor Activity Nuclear Aryl Hydrocarbon Receptor Complex Intracellular Receptor Signaling Pathway Nuclear Estrogen Receptor Activity Aryl Hydrocarbon Receptor Complex Intestinal Epithelial Structure Maintenance Estrogen Response Element Binding DNA-binding Transcription Factor Activity Maintenance Of Gastrointestinal Epithelium Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity TBP-class Protein Binding Transcription Regulator Complex Steroid Binding Epithelial Structure Maintenance Cellular Response To Estradiol Stimulus Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding Regulation Of Inflammatory Response Positive Regulation Of Transcription By RNA Polymerase II Digestive System Process Cellular Response To Lipid Sequence-specific DNA Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding Cytosolic Aryl Hydrocarbon Receptor Complex Nuclear Receptor-mediated Signaling Pathway Sequence-specific Double-stranded DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Estradiol Positive Regulation Of DNA-binding Transcription Factor Activity Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Response To Lipid Signal Transduction Protein Dimerization Activity Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Defense Response DNA Binding Negative Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity
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