TNFRSF25 and TRADD

Number of citations of the paper that reports this interaction (PMID 8934525)
45

Data Source:
HPRD (two hybrid, in vivo)

		TNFRSF25	TRADD
Gene Name		tumor necrosis factor receptor superfamily, member 25	TNFRSF1A-associated via death domain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Cytoplasm Cytosol Cytoskeleton Death-inducing Signaling Complex Receptor Complex Membrane Raft
	Molecular Function	Receptor Activity Tumor Necrosis Factor-activated Receptor Activity	Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Kinase Binding Protein Complex Binding Identical Protein Binding Binding, Bridging Death Domain Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Positive Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Regulation by c-FLIP Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: BAG4 DAP3 MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2	24 interactors: BCL10 BIRC2 CNTRL DAPK1 FADD FAS GFRA1 HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP
Entrez ID		8718	8717
HPRD ID		04532	04610
Ensembl ID		ENSG00000215788
Uniprot IDs		Q93038	B3KQZ9 Q15628
PDB IDs			1F2H 1F3V
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To Tumor Necrosis Factor Positive Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Protein Heterooligomerization Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Response To Cytokine Positive Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Signal Transduction Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Signaling Zymogen Activation Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Oligomerization Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Endopeptidase Activity Signaling Cell Communication Positive Regulation Of Peptidase Activity Regulation Of Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Response To Epidermal Growth Factor Regulation Of Phosphorus Metabolic Process	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Signaling Pathway Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Tumor Necrosis Factor Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Peptidase Activity Cell Surface Receptor Signaling Pathway Regulation Of Endopeptidase Activity Cellular Response To Cytokine Stimulus Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Response To Cytokine Programmed Necrotic Cell Death Necrotic Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Organic Substance Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Necroptotic Signaling Pathway Zymogen Activation Negative Regulation Of Apoptotic Process Cellular Response To Organic Substance Signal Transduction Negative Regulation Of Programmed Cell Death Response To Mechanical Stimulus Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Necroptotic Process Signaling Cellular Response To Mechanical Stimulus Cell Communication Response To Abiotic Stimulus
Tagcloud ?		asp bel7404 carboxy cip1 cited2 clonogenicity glu granzyme hccs hep3b ink4b kip1 lo2 maspin metallopeptidase nontumor oligonucleotide ontology p15 peroxisome ppargamma proapoptotic proinvasion proliferator rosiglitazone suppressive transactivator wat1	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr traf traf1 transmit
Tagcloud (Difference) ?		asp bel7404 carboxy cip1 cited2 clonogenicity glu granzyme hccs hep3b ink4b kip1 lo2 maspin metallopeptidase nontumor oligonucleotide ontology p15 peroxisome ppargamma proapoptotic proinvasion proliferator rosiglitazone suppressive transactivator wat1	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr traf traf1 transmit
Tagcloud (Intersection) ?