TNFRSF25 and SLC2A5

		TNFRSF25	SLC2A5
Description		TNF receptor superfamily member 25	solute carrier family 2 member 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane	Plasma Membrane Membrane Apical Plasma Membrane Specific Granule Membrane Sarcolemma Extracellular Exosome
	Molecular Function	Tumor Necrosis Factor Receptor Activity Signaling Receptor Activity	Fructose Transmembrane Transporter Activity Protein Binding Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity Fructose Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway	Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Carbohydrate Metabolic Process Response To Fructose Fructose Transmembrane Transport D-glucose Import Transmembrane Transport Dehydroascorbic Acid Transport Cellular Response To Fructose Stimulus Intestinal Hexose Absorption D-glucose Transmembrane Transport Fructose Import Across Plasma Membrane
Pathways		TNFs bind their physiological receptors	Neutrophil degranulation Intestinal hexose absorption
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: BAG4 DAP3 DYRK1A MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2	15 interacting genes: ARL13B ATP6V0B CCL5 COMT EVI2B FCRL3 LMNA MGST3 MTERF3 PAGE1 RPSA SCN3B TMEM130 TMEM237 USP40
Entrez ID		8718	6518
HPRD ID		04532	00690
Ensembl ID		ENSG00000215788	ENSG00000142583
Uniprot IDs		Q93038	A0A140VJK5 B4DG19 B4DT82 P22732
PDB IDs		5YGP 5YGS
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Superfamily Complex Non-canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Binding Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Tumor Necrosis Factor Negative Regulation Of MRNA Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Response To Tumor Necrosis Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Intracellular Signaling Cassette Regulation Of Apoptotic Process Receptor Complex Regulation Of Programmed Cell Death Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Histone H3T45 Kinase Activity Diuretic Hormone Activity Positive Regulation Of Protein Phosphorylation Response To Epidermal Growth Factor Fructose Import Across Plasma Membrane Positive Regulation Of Signal Transduction TORC2 Complex Disassembly Negative Regulation Of MRNA Modification Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Cytosine Metabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly
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