KLF8

Description		KLF transcription factor 8
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Aggresome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Male-pattern baldness ( 27182965 28196072)
Interacting Genes		6 interacting genes: APP CTBP2 FHL3 NFIA NFIB NFIC
Entrez ID		11279
HPRD ID		02238
Ensembl ID		ENSG00000102349
Uniprot IDs		O95600 Q05BZ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Glial Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II DNA Replication Exit From Mitosis Viral Genome Replication Generation Of Neurons Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of MiRNA Transcription Positive Regulation Of DNA-templated Transcription Neuron Fate Specification Glial Cell Proliferation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Amylin Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Retina Development In Camera-type Eye DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Fate Specification Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation Positive Regulation Of Biosynthetic Process Acetylcholine Receptor Activator Activity Anatomical Structure Morphogenesis Negative Regulation Of RNA Metabolic Process Lipoprotein Particle Developmental Process Positive Regulation Of Protein Import Neurogenesis Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Positive Regulation Of Macromolecule Metabolic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production
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