NFE2L3

Description		NFE2 like bZIP transcription factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Integrated Stress Response Signaling
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Body mass index ( 23583978) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Endometriosis ( 28333195) Gamma glutamyl transferase levels ( 29403010 33339817) Height ( 31562340) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 33339817 29403010) Obesity-related traits ( 23251661) Phoneme awareness ( 30741946) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Superior frontal gyrus grey matter volume ( 25335168) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 33339817 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		9 interacting genes: BACH2 CREB3 DSCR9 GSK3B MAFK NFE2 NFE2L1 NFE2L2 PPARG
Entrez ID		9603
HPRD ID		09162
Ensembl ID		ENSG00000050344
Uniprot IDs		Q9Y4A8
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Integrated Stress Response Signaling Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase II Response To Endoplasmic Reticulum Stress DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of RNA Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Cellular Response To Copper Ion WW Domain Binding Negative Regulation Of Stem Cell Differentiation Positive Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Response To Copper Ion ER-nucleus Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cell Redox Homeostasis Protein-DNA Complex Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Osteoblast Differentiation Regulation Of Microtubule Anchoring At Centrosome Regulation Of Nucleus Organization Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Glutathione Biosynthetic Process Positive Regulation Of Deacetylase Activity Primary Adaptive Immune Response Involving T Cells And B Cells Negative Regulation Of Cell Migration Positive Regulation Of Transport
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