NFE2L3 and BACH2

Number of citations of the paper that reports this interaction (PubMedID 23661758)
48

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NFE2L3	BACH2
Description		NFE2 like bZIP transcription factor 3	BACH transcriptional regulator 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Integrated Stress Response Signaling	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Import Into Nucleus Primary Adaptive Immune Response Involving T Cells And B Cells
Pathways
Drugs
Diseases			Type I diabetes mellitus
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Body mass index ( 23583978) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Endometriosis ( 28333195) Gamma glutamyl transferase levels ( 29403010 33339817) Height ( 31562340) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 33339817 29403010) Obesity-related traits ( 23251661) Phoneme awareness ( 30741946) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Superior frontal gyrus grey matter volume ( 25335168) Total cholesterol levels ( 29403010 33339817) Triglyceride levels ( 33339817 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Addison's disease ( 33574239) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 29273806 34103634 32296059 31959851 31619474 31361310 30929738 27182965) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203 33549134) Basophil count ( 32888494) Celiac disease ( 30572963 20190752 24999842 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive performance ( 20125193) Crohn's disease ( 28067908 21102463) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Graves' disease ( 22922229 21841780) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Interleukin-6 levels ( 22205395) Keratinocyte cancer (MTAG) ( 31174203) Latent autoimmune diabetes ( 30254083) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602 21833088) Nasal polyps ( 30643255) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Primary central nervous system lymphoma ( 31102405) Primary sclerosing cholangitis ( 27992413 23603763) Red blood cell count ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Rheumatoid arthritis ( 30572963 23143596) Serum urate levels in chronic kidney disease ( 30181573) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33272962 23273568 27399966) Thyroid peroxidase antibody positivity ( 24586183) Thyroid peroxidase autoantibody levels in type 1 diabetes ( 21829393) Type 1 diabetes ( 19430480 18978792 21829393 30572963 18840781 25751624) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494 27863252)
Interacting Genes		9 interacting genes: BACH2 CREB3 DSCR9 GSK3B MAFK NFE2 NFE2L1 NFE2L2 PPARG	45 interacting genes: ANKRD55 AP1M1 BAHD1 BATF3 CBX8 CCDC185 CENPP CFAP58 CTSZ CWF19L2 DDIT3 ELOA ENPP7 FAM161A FARS2 FOSL2 FUS HMG20A INSYN2A KAT5 LUZP4 MAFF MAFK MCRS1 MLX NFE2L1 NFE2L3 NXF1 PATZ1 PSMC5 RPL9 RPP25 SCNM1 SLC43A1 SMYD1 TCEA2 TRAF4 TRIM42 TSHZ2 TULP3 ZBTB24 ZNF124 ZNF438 ZNF774 ZNF792
Entrez ID		9603	60468
HPRD ID		09162	12012
Ensembl ID		ENSG00000050344	ENSG00000112182
Uniprot IDs		Q9Y4A8	Q9BYV9
PDB IDs			3OHU 3OHV
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Integrated Stress Response Signaling Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase II Response To Endoplasmic Reticulum Stress DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of RNA Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Cellular Response To Copper Ion WW Domain Binding Negative Regulation Of Stem Cell Differentiation Positive Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Response To Copper Ion ER-nucleus Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cell Redox Homeostasis Protein-DNA Complex Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Osteoblast Differentiation Regulation Of Microtubule Anchoring At Centrosome Regulation Of Nucleus Organization Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Glutathione Biosynthetic Process Positive Regulation Of Deacetylase Activity Primary Adaptive Immune Response Involving T Cells And B Cells Negative Regulation Of Cell Migration Positive Regulation Of Transport	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Zinc Ion Binding Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Integrated Stress Response Signaling Chromatin Binding Positive Regulation Of DNA Repair Regulation Of Myoblast Differentiation
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