RPL11 and TIGAR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPL11	TIGAR
Description		ribosomal protein L11	TP53 induced glycolysis regulatory phosphatase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Extracellular Exosome Ribonucleoprotein Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding RRNA Binding Ubiquitin Protein Ligase Binding Ubiquitin Ligase Inhibitor Activity	Catalytic Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Ribosomal Large Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Protein Targeting Positive Regulation Of Gene Expression Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Ribosomal Large Subunit Biogenesis Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation	Mitophagy Response To Ischemia Fructose 2,6-bisphosphate Metabolic Process Glycolytic Process Autophagy Apoptotic Process Response To Stress DNA Damage Response Response To Xenobiotic Stimulus Response To Gamma Radiation Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Pentose-phosphate Shunt Positive Regulation Of DNA Repair Negative Regulation Of Glycolytic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Phosphate Metabolic Process Intestinal Epithelial Cell Development Cellular Response To Cobalt Ion Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Negative Regulation Of Mitophagy Regulation Of Response To DNA Damage Checkpoint Signaling Positive Regulation Of Hexokinase Activity Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Positive Regulation Of Pentose-phosphate Shunt Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	TP53 Regulates Metabolic Genes
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases		Diamond-Blackfan anemia (DBA)
GWAS
Interacting Genes		25 interacting genes: APP ARFGAP1 BLMH CAMK2B CDKN2A DVL3 GRWD1 HP HSPB2 IGF1R IP6K1 KRT40 KRTAP10-7 LIG4 MDM2 OGT OSBPL3 PAIP2 PCAT1 PML SENP1 STAT3 TIGAR TP73 UBE2I	3 interacting genes: APP NFE2L2 RPL11
Entrez ID		6135	57103
HPRD ID		10364	12610
Ensembl ID		ENSG00000142676	ENSG00000078237
Uniprot IDs		P62913 Q5VVD0	Q9NQ88
PDB IDs		4UG0 4V6X 4XXB 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8BGU 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	3DCY
Enriched GO Terms of Interacting Partners?		SUMO Transferase Activity Protein Sumoylation Regulation Of Glycolytic Process Negative Regulation Of Catabolic Process Response To Gamma Radiation Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of ATP Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Amyloid Fibril Formation Regulation Of Cellular Response To Stress Positive Regulation Of Developmental Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cytosol Regulation Of Proteolysis Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Programmed Cell Death Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Hydrogen Peroxide Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Generation Of Precursor Metabolites And Energy Oncogene-induced Cell Senescence Positive Regulation Of Apoptotic Process Involved In Morphogenesis Negative Regulation Of Translational Initiation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Involved In Development Response To Ionizing Radiation Response To Xenobiotic Stimulus Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of Cellular Component Organization Somatic Stem Cell Population Maintenance MDM2/MDM4 Family Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Protein Localization To Nucleus P53 Binding Autophagy Of Mitochondrion Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Carbohydrate Homeostasis Glucose Homeostasis	Response To Copper Ion Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Superoxide Metabolic Process Cellular Response To Copper Ion Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Glutathione Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Gene Expression Positive Regulation Of Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Proteasomal Ubiquitin-independent Protein Catabolic Process Toxin Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Differentiation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon
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