RPL11 and C12orf5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RPL11	C12orf5
Gene Name		ribosomal protein L11	chromosome 12 open reading frame 5
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytosol Membrane Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome	Intracellular
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding RRNA Binding Poly(A) RNA Binding	Fructose-2,6-bisphosphate 2-phosphatase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination Protein Targeting SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Protein Localization To Nucleus Ribosomal Large Subunit Biogenesis Cellular Protein Metabolic Process	Response To Xenobiotic Stimulus Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Dephosphorylation Intestinal Epithelial Cell Development Negative Regulation Of Macromitophagy Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 19684603) Colorectal cancer ( 23263487) Major depressive disorder ( 23377640)
Protein-Protein Interactions		14 interactors: ARFGAP1 BLMH C12orf5 CAMK2B HP IGF1R KRT40 KRTAP10-7 LIG4 MDM2 NEDD8 PAIP2 PML STAT3	2 interactors: APP RPL11
Entrez ID		6135	57103
HPRD ID		10364	12610
Ensembl ID		ENSG00000142676
Uniprot IDs		P62913 Q5VVD0	Q9NQ88
PDB IDs		3J3B	3DCY
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Response To Gamma Radiation Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Immune System Process Regulation Of Apoptotic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Ionizing Radiation Response To Radiation Response To Inorganic Substance Response To Stimulus Regulation Of Cell Cycle Process Response To Organic Substance Protein Localization To Nucleus Viral Process Response To Abiotic Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Acute-phase Response Positive Regulation Of Cell Death Negative Regulation Of Reactive Oxygen Species Metabolic Process Immune Response Defense Response Regulation Of Muscle Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Catalytic Activity Regulation Of Cell Proliferation Cellular Response To Peptide Response To Metal Ion Negative Regulation Of Cellular Protein Metabolic Process Response To Stress Negative Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Translation In Response To Oxidative Stress DNA Ligation Involved In DNA Recombination Cellular Response To UV-C Inactivation Of MAPKK Activity Cellular Response To Vitamin B1 Inhibitory G-protein Coupled Receptor Phosphorylation Somatic Stem Cell Maintenance Cellular Response To Stress Proteolysis Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint	Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition MRNA Metabolic Process Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Ribosomal Large Subunit Biogenesis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Intracellular Transport Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Establishment Of Localization In Cell Viral Transcription Regulation Of Synapse Structure Or Activity Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Feeding Behavior
Tagcloud ?		actinomycin biogenesis blunted blunting blunts caffeine chemotherapeutics combinatorial connected destabilize glioma indeed insults ly294 master mechanistic mimicked mtor nucleolar osteosarcoma pp242 rapamycin ribosome simultaneous stabilization temsirolimus triggered whereby wortmannin	11q13 12p13 ac008012 ac103292 adhr bioinformatics ccnd2 clustered cp2 e47 fgf19 fgf23 fgf4 fgf6 genomics hypophosphatemia hypophosphatemic igcr infiltrating intergenic oraov1 osteomalacia paralogons paralogous paraneoplastic pax4 rickets tio undermineralization
Tagcloud (Difference) ?		actinomycin biogenesis blunted blunting blunts caffeine chemotherapeutics combinatorial connected destabilize glioma indeed insults ly294 master mechanistic mimicked mtor nucleolar osteosarcoma pp242 rapamycin ribosome simultaneous stabilization temsirolimus triggered whereby wortmannin	11q13 12p13 ac008012 ac103292 adhr bioinformatics ccnd2 clustered cp2 e47 fgf19 fgf23 fgf4 fgf6 genomics hypophosphatemia hypophosphatemic igcr infiltrating intergenic oraov1 osteomalacia paralogons paralogous paraneoplastic pax4 rickets tio undermineralization
Tagcloud (Intersection) ?