DCUN1D1 and CUL2

Number of citations of the paper that reports this interaction (PMID 18826954)
22

Data Source:
BioGRID (enzymatic study)

		DCUN1D1	CUL2
Gene Name		DCN1, defective in cullin neddylation 1, domain containing 1	cullin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex	Nucleoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Biological_process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway
Pathways			Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ARRDC3 AURKB CALM1 CAND1 CUL2 CUL3 CUL4A CUL4B DAZAP2 LAPTM5 LZTS2 NEDD4 NEDD8 RHOA RNF11 SMAD2 TP53BP2 TRIM39 TRIM54 UBE2F VPS37B	20 interactors: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D1 DCUN1D4 GPS1 KAT2A MKNK2 NEDD8 PRAME RNF7 SAP130 SENP8 TCEB1 UBE2D1 VHL ZER1 ZYG11B
Entrez ID		54165	8453
HPRD ID		12067	06786
Ensembl ID			ENSG00000108094
Uniprot IDs		C9JVE2 Q96GG9	Q13617
PDB IDs		3TDU 3TDZ
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Regulation Of Cytokinesis Cellular Macromolecule Catabolic Process Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Process Cellular Response To Light Stimulus Cellular Protein Modification Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Positive Regulation Of Cytokinesis Cellular Response To Radiation Catabolic Process Protein Monoubiquitination Cell Cycle Cleavage Furrow Formation Positive Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway Proteolysis Cellular Response To UV Protein Neddylation Mitotic Cell Cycle Regulation Of Signal Transduction Response To Radiation Negative Regulation Of Cell Cycle Spindle Midzone Assembly Cellular Protein Metabolic Process Spindle Assembly Regulation Of Cell Division Regulation Of Signaling Developmental Process Viral Process Protein Metabolic Process Cytokinesis Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Protein Complex Assembly Cell Cycle Process Positive Regulation Of Cell Division Response To Light Stimulus Spindle Organization Cellular Protein Complex Assembly	Cellular Protein Modification Process Protein Deneddylation Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Modification By Small Protein Removal Protein Ubiquitination Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cullin Deneddylation Protein Neddylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Proteolysis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Histone H3 Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Protein Catabolic Process Transcription, DNA-templated Response To Hypoxia RNA Biosynthetic Process SCF Complex Assembly Regulation Of Cellular Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Exosomal Secretion Protein Deubiquitination Histone Acetylation
Tagcloud ?		achilles adapter adapters amplicons amplifications amplified atlas backgrounds bioinformatics datasets driver druggable emphasis fgfr frs2 gistic2 grb7 hedgehog kras narrowed nsd3 pik3ca projects putative referencing shrna spanning tailoring tcga	adrenal arise bc chromaffin cnl copy disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic rbx1 tceb1 tceb2 vhl von
Tagcloud (Difference) ?		achilles adapter adapters amplicons amplifications amplified atlas backgrounds bioinformatics datasets driver druggable emphasis fgfr frs2 gistic2 grb7 hedgehog kras narrowed nsd3 pik3ca projects putative referencing shrna spanning tailoring tcga	adrenal arise bc chromaffin cnl copy disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic rbx1 tceb1 tceb2 vhl von
Tagcloud (Intersection) ?