RPL10A and DUX4

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (pull down)

		RPL10A	DUX4
Description		ribosomal protein L10a	double homeobox 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Nuclear Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cytoplasmic Translation Translation Response To Ethanol	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Zygotic genome activation (ZGA) Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: ACTB DUX4 OGT PTEN RGS17 SGO1 SRPRA YWHAQ	124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1
Entrez ID		4736	100288687
HPRD ID		10199
Ensembl ID		ENSG00000198755	ENSG00000260596
Uniprot IDs		P62906	C3U3A0 Q9UBX2
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6LQM 6LSR 6LU8 6OLG 6QZP 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FL2 8FL3 8FL4 8G5Y 8G60 8G61 8G6J 8IDY 8IFD 8IFE 8INF 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFC 8UKB 8XSX 8XSY 8Y0W 8YOP	5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82
Enriched GO Terms of Interacting Partners?		Synapse Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Regulation Of G0 To G1 Transition Substantia Nigra Development Neural Nucleus Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Norepinephrine Uptake Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Protein Localization To Cell Periphery Regulation Of Transepithelial Transport Axonogenesis Regulation Of Protein Localization To Membrane Protein Localization To Adherens Junction Dense Body Regulation Of Cell Cycle G1/S Phase Transition Transporter Regulator Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Morphogenesis Of A Polarized Epithelium Kinetochore Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Circadian Rhythm Rhythmic Synaptic Transmission Postsynaptic Density Assembly Signal Recognition Particle Receptor Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Mitotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of G0 To G1 Transition BBAF Complex	RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Cytosolic Small Ribosomal Subunit Macromolecule Biosynthetic Process Cytosol Extracellular Exosome Cytoplasm Nucleolus Ribonucleoprotein Complex Biogenesis Macromolecule Metabolic Process Small Ribosomal Subunit Nucleus Ribosomal Small Subunit Biogenesis Membrane Protein Metabolic Process Small-subunit Processome MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA 5'-UTR Binding Nucleic Acid Metabolic Process Large Ribosomal Subunit RNA Processing Synapse Positive Regulation Of Cytoplasmic Translation Catalytic Step 2 Spliceosome Regulation Of Translation RRNA Metabolic Process RRNA Binding Post-transcriptional Regulation Of Gene Expression CRD-mediated MRNA Stabilization Positive Regulation Of Translation Double-stranded RNA Binding Regulation Of Cytoplasmic Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RRNA Processing Spliceosomal Complex Nucleic Acid Binding RNA Splicing Cadherin Binding Cellular Response To Cytokine Stimulus Nucleotide Binding
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