NDUFS2 and HMOX2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NDUFS2	HMOX2
Description		NADH:ubiquinone oxidoreductase core subunit S2	heme oxygenase 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Respiratory Chain Complex I	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Oxygen Sensor Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Quinone Binding NAD Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Heme Oxygenase (decyclizing) Activity Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Neurogenesis Mitochondrial Respiratory Chain Complex I Assembly Gliogenesis Mitochondrial ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Neural Precursor Cell Proliferation Cellular Response To Oxygen Levels Proton Transmembrane Transport	Response To Hypoxia Heme Oxidation Response To Oxidative Stress Heme Catabolic Process
Pathways		Respiratory electron transport Complex I biogenesis	Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1
Drugs		NADH	NADH Stannsoporfin
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 30929738 31361310 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Granulocyte percentage of myeloid white cells ( 27863252)	Erectile dysfunction ( 30583798)
Interacting Genes		6 interacting genes: APP CENPU EGR2 HMOX2 TNFRSF14 UBC	67 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BIK BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LRIF1 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PCNT PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746
Entrez ID		4720	3163
HPRD ID		04285	00783
Ensembl ID		ENSG00000158864	ENSG00000103415
Uniprot IDs		A0A7I2V4G5 B7Z792 O75306	A0A087WT44 B3KSE0 P30519
PDB IDs		5XTB 5XTC 5XTD 5XTH 5XTI	2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of T Cell Migration Regulation Of Lymphocyte Migration Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Rhombomere 5 Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Ubiquitin Protein Ligase Binding Defense Response To Gram-negative Bacterium Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Mononuclear Cell Migration Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Receptor Ligand Activity Lipoprotein Particle Regulation Of Mononuclear Cell Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Rhombomere 3 Development Positive Regulation Of Schwann Cell Differentiation Brain Segmentation Heme Oxidation Heme Oxygenase (decyclizing) Activity Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of Leukocyte Migration Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Schwann Cell Differentiation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon	Membrane Protein Binding
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