NDUFS2 and CENPU

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NDUFS2	CENPU
Description		NADH:ubiquinone oxidoreductase core subunit S2	centromere protein U
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Respiratory Chain Complex I	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Centriolar Satellite
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Oxygen Sensor Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Quinone Binding NAD Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Neurogenesis Mitochondrial Respiratory Chain Complex I Assembly Gliogenesis Mitochondrial ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Neural Precursor Cell Proliferation Cellular Response To Oxygen Levels Proton Transmembrane Transport	Chromosome Segregation Chordate Embryonic Development
Pathways		Respiratory electron transport Complex I biogenesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 30929738 31361310 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Granulocyte percentage of myeloid white cells ( 27863252)
Interacting Genes		6 interacting genes: APP CENPU EGR2 HMOX2 TNFRSF14 UBC	20 interacting genes: CENPQ E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 OGT PGRMC1 PLK1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6
Entrez ID		4720	79682
HPRD ID		04285	14722
Ensembl ID		ENSG00000158864	ENSG00000151725
Uniprot IDs		A0A7I2V4G5 B7Z792 O75306	Q71F23
PDB IDs		5XTB 5XTC 5XTD 5XTH 5XTI	7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH 8K4D
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of T Cell Migration Regulation Of Lymphocyte Migration Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Rhombomere 5 Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Ubiquitin Protein Ligase Binding Defense Response To Gram-negative Bacterium Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Mononuclear Cell Migration Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Receptor Ligand Activity Lipoprotein Particle Regulation Of Mononuclear Cell Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Rhombomere 3 Development Positive Regulation Of Schwann Cell Differentiation Brain Segmentation Heme Oxidation Heme Oxygenase (decyclizing) Activity Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of Leukocyte Migration Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Schwann Cell Differentiation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon	Regulation Of Cellular Component Organization Spindle Pole Regulation Of Cytokinesis Positive Regulation Of Protein Localization Regulation Of Cell Cycle Process Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Cell Division Regulation Of Protein Localization Centrosome Separation Regulation Of Protein-containing Complex Assembly Cytoskeleton Regulation Of Cell Cycle Negative Regulation Of Cellular Component Organization Negative Regulation Of Synapse Organization Cell Junction Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Spindle Organization Synapse Organization Organelle Organization Regulation Of Microtubule-based Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation In Response To Stress Regulation Of Synapse Organization Regulation Of Centriole Replication Negative Regulation Of Macromolecule Biosynthetic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Telomeric DNA Binding Negative Regulation Of Protein-containing Complex Assembly Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Spindle Organization Regulation Of Protein Catabolic Process Centrosome Cell Cycle Phase Transition Kinetochore Regulation Of Synapse Assembly Negative Regulation Of Catabolic Process Positive Regulation Of Translation Regulation Of Microtubule Cytoskeleton Organization Mitotic Spindle Pole Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Autophagy Regulation Of Protein Metabolic Process Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly
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