NDUFA7 and TTPA

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NDUFA7	TTPA
Name		NADH:ubiquinone oxidoreductase subunit A7	alpha tocopherol transfer protein
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I	Cytoplasm Late Endosome Cytosol
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Placenta Development Embryonic Placenta Development Lipid Metabolic Process Response To Toxic Substance Vitamin E Metabolic Process Vitamin Transport Negative Regulation Of Establishment Of Blood-brain Barrier Intermembrane Lipid Transfer Positive Regulation Of Amyloid-beta Clearance
Pathways		Respiratory electron transport Complex I biogenesis	Vitamin E transport
Drugs		NADH	None
Diseases		None	Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS		No GWAS studies recorded	Response to esketamine (responder status) in treatment resistant depression ( 32724131 ) Response to esketamine in treatment resistant depression ( 32724131 )
Novel Interactors		None recorded	1 novel interactors: MMS22L
Interacting Genes		8 interacting genes: ELAC2 LMO1 MDFI PRKAB1 RTP2 STARD9 TTPA UPF2	46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52
Entrez ID		4701	7274
HPRD ID		11885	02685
Ensembl ID		ENSG00000267855	ENSG00000137561
Uniprot IDs		O95182	P49638
PDB IDs		5XTB 5XTD 5XTH 5XTI	1OIP 1OIZ 1R5L 5MUE 5MUG 6ZPD
GO Terms Enriched among Interactors		None	Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Very-low-density Lipoprotein Particle Lipoprotein Lipase Activator Activity High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Intermediate Filament Lipoprotein Metabolic Process Keratin Filament Positive Regulation Of Triglyceride Catabolic Process Trans-Golgi Network Membrane Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Phospholipid Efflux