TTPA and COQ3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TTPA	COQ3
Description		alpha tocopherol transfer protein	coenzyme Q3, methyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Late Endosome Cytosol	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Extrinsic Component Of Mitochondrial Inner Membrane Ubiquinone Biosynthesis Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding	Protein Binding Methyltransferase Activity O-methyltransferase Activity Polyprenyldihydroxybenzoate Methyltransferase Activity Transferase Activity 3-demethylubiquinol 3-O-methyltransferase Activity 3-demethylubiquinone 3-O-methyltransferase Activity
	Biological Process	Placenta Development Embryonic Placenta Development Lipid Metabolic Process Response To Toxic Substance Vitamin E Metabolic Process Vitamin Transport Negative Regulation Of Establishment Of Blood-brain Barrier Intermembrane Lipid Transfer Positive Regulation Of Amyloid-beta Clearance	Glycerol Metabolic Process Ubiquinone Biosynthetic Process Methylation
Pathways		Vitamin E transport	Ubiquinol biosynthesis
Drugs
Diseases		Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS		Response to esketamine (responder status) in treatment resistant depression ( 32724131) Response to esketamine in treatment resistant depression ( 32724131)	Regular attendance at a religious group ( 29970889)
Interacting Genes		46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52	4 interacting genes: NDRG4 PTPN9 SNX1 TTPA
Entrez ID		7274	51805
HPRD ID		02685	07283
Ensembl ID		ENSG00000137561	ENSG00000132423
Uniprot IDs		P49638	Q9NZJ6
PDB IDs		1OIP 1OIZ 1R5L 5MUE 5MUG 6ZPD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Very-low-density Lipoprotein Particle Lipoprotein Lipase Activator Activity High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Intermediate Filament Lipoprotein Metabolic Process Keratin Filament Positive Regulation Of Triglyceride Catabolic Process Trans-Golgi Network Membrane Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Phospholipid Efflux	Retromer, Tubulation Complex Leptin Receptor Binding Negative Regulation Of Establishment Of Blood-brain Barrier Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Vitamin E Metabolic Process Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Cellular Localization Regulation Of Neuron Projection Development Neuron Projection Terminus Peptidyl-tyrosine Dephosphorylation Lipid Binding Transferrin Receptor Binding Early Endosome To Golgi Transport Lamellipodium Morphogenesis Retromer Complex Insulin Receptor Binding Phosphatidylinositol Bisphosphate Binding Lipid Transfer Activity Positive Regulation Of Amyloid-beta Clearance Regulation Of Amyloid-beta Clearance Regulation Of Endocytic Recycling Embryonic Heart Tube Development Cell Projection Membrane Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cell Migration Involved In Heart Development Embryonic Placenta Development Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
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