TTPA and BIRC7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TTPA	BIRC7
Description		alpha tocopherol transfer protein	baculoviral IAP repeat containing 7
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GO Annotations	Cellular Component	Cytoplasm Late Endosome Cytosol	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Peptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Placenta Development Embryonic Placenta Development Lipid Metabolic Process Response To Toxic Substance Vitamin E Metabolic Process Vitamin Transport Negative Regulation Of Establishment Of Blood-brain Barrier Intermembrane Lipid Transfer Positive Regulation Of Amyloid-beta Clearance	Lens Development In Camera-type Eye Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Regulation Of Natural Killer Cell Apoptotic Process
Pathways		Vitamin E transport	Regulation of MITF-M-dependent genes involved in apoptosis
Drugs
Diseases		Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS		Response to esketamine (responder status) in treatment resistant depression ( 32724131) Response to esketamine in treatment resistant depression ( 32724131)
Interacting Genes		46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52	37 interacting genes: AURKC BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 DDX6 DIABLO FAM124B GTF2A1 HTRA2 KANK2 LCOR LMO4 NTAQ1 PHF1 POLR1C PRR35 PSMB1 PTCD3 QARS1 SOX5 TEPSIN TLE5 TNPO2 TSGA10IP TTPA UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2I UBE2K USP2 VPS37C XAF1
Entrez ID		7274	79444
HPRD ID		02685	05761
Ensembl ID		ENSG00000137561	ENSG00000101197
Uniprot IDs		P49638	Q96CA5
PDB IDs		1OIP 1OIZ 1R5L 5MUE 5MUG 6ZPD	1OXN 1OXQ 1OY7 1TW6 2I3H 2I3I 3F7G 3F7H 3F7I 3GT9 3GTA 3UW5 4AUQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Very-low-density Lipoprotein Particle Lipoprotein Lipase Activator Activity High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Intermediate Filament Lipoprotein Metabolic Process Keratin Filament Positive Regulation Of Triglyceride Catabolic Process Trans-Golgi Network Membrane Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Phospholipid Efflux	Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Metabolic Process Macromolecule Catabolic Process Fibroblast Apoptotic Process Iron-sulfur Cluster Assembly Complex Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Neuron Apoptotic Process Nucleus Cysteine-type Endopeptidase Activity Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Iron-sulfur Cluster Assembly Execution Phase Of Apoptosis Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Staurosporine Cytosol Negative Regulation Of Biosynthetic Process Glial Cell Apoptotic Process Protein Maturation Post-translational Protein Modification Response To Interferon-beta Response To Anesthetic Negative Regulation Of Metabolic Process Cell Redox Homeostasis Protein Binding Negative Regulation Of Macromolecule Metabolic Process Leukocyte Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Cysteine-type Peptidase Activity Response To Cobalt Ion Ubiquitin-protein Transferase Activity [2Fe-2S] Cluster Assembly CD40 Receptor Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Intracellular Iron Ion Homeostasis Protein Modification Process Positive Regulation Of Neuron Apoptotic Process Catabolic Process Apoptotic Process Intrinsic Apoptotic Signaling Pathway Histone Methyltransferase Binding Negative Regulation Of RNA Metabolic Process Protein Processing Protein Poly-ADP-ribosylation Programmed Cell Death
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