TTPA and SYNGR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TTPA	SYNGR3
Description		alpha tocopherol transfer protein	synaptogyrin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Late Endosome Cytosol	Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Synapse
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding	Protein Binding SH2 Domain Binding
	Biological Process	Placenta Development Embryonic Placenta Development Lipid Metabolic Process Response To Toxic Substance Vitamin E Metabolic Process Vitamin Transport Negative Regulation Of Establishment Of Blood-brain Barrier Intermembrane Lipid Transfer Positive Regulation Of Amyloid-beta Clearance	Regulation Of Synaptic Vesicle Priming Substantia Nigra Development Positive Regulation Of Transporter Activity Regulated Exocytosis Regulation Of Neurotransmitter Uptake
Pathways		Vitamin E transport
Drugs
Diseases		Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS		Response to esketamine (responder status) in treatment resistant depression ( 32724131) Response to esketamine in treatment resistant depression ( 32724131)
Interacting Genes		46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52	14 interacting genes: ACSF2 ARFIP1 EHHADH GAD2 GLP1R HSBP1L1 MIDN MPP1 NDRG4 PLIN3 PNKP SH3GLB1 SPG21 TTPA
Entrez ID		7274	9143
HPRD ID		02685	06801
Ensembl ID		ENSG00000137561	ENSG00000127561
Uniprot IDs		P49638	O43761
PDB IDs		1OIP 1OIZ 1R5L 5MUE 5MUG 6ZPD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Very-low-density Lipoprotein Particle Lipoprotein Lipase Activator Activity High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Intermediate Filament Lipoprotein Metabolic Process Keratin Filament Positive Regulation Of Triglyceride Catabolic Process Trans-Golgi Network Membrane Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Phospholipid Efflux
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