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TTPA and ARMC12
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
TTPA
ARMC12
Description
alpha tocopherol transfer protein
armadillo repeat containing 12
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Late Endosome
Cytosol
Nucleus
Mitochondrion
Mitochondrial Outer Membrane
Membrane
Molecular Function
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Lipid Binding
Vitamin E Binding
Phosphatidylinositol-3,4-bisphosphate Binding
Lipid Transfer Activity
Phosphatidylinositol Bisphosphate Binding
Protein Binding
Biological Process
Placenta Development
Embryonic Placenta Development
Lipid Metabolic Process
Response To Toxic Substance
Vitamin E Metabolic Process
Vitamin Transport
Negative Regulation Of Establishment Of Blood-brain Barrier
Intermembrane Lipid Transfer
Positive Regulation Of Amyloid-beta Clearance
Spermatogenesis
Cell Differentiation
Positive Regulation Of Cell Growth
Flagellated Sperm Motility
Sperm Mitochondrial Sheath Assembly
Pathways
Vitamin E transport
Drugs
Diseases
Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS
Response to esketamine (responder status) in treatment resistant depression (
32724131
)
Response to esketamine in treatment resistant depression (
32724131
)
Depression x herpes simplex 1 infection interaction (
32564518
)
Eosinophil percentage of granulocytes (
27863252
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
46 interacting genes:
AGTRAP
APOA5
APOC2
APP
ARFIP2
ARMC12
BIRC7
CISD2
CMTM4
CMTM5
COQ3
CYSRT1
DGAT2L6
DHODH
FADS6
FAM114A2
FAM25A
FAM25C
FAM25G
FGF14
FKBP7
GOLGA2
HSD17B11
JOSD2
KRTAP10-7
KRTAP12-2
KRTAP12-3
KRTAP2-3
KRTAP2-4
LEUTX
MAL2
MRM1
NBPF19
NDUFA7
NOTCH2NLA
PEX12
REEP2
RPRM
SAR1A
SCAMP1
SCAMP5
SDR16C5
SLC35E3
SYNGR3
THAP4
TPD52
8 interacting genes:
EHHADH
FA2H
GAD2
RBBP4
SENP2
SNX1
SPG21
TTPA
Entrez ID
7274
221481
HPRD ID
02685
12901
Ensembl ID
ENSG00000137561
ENSG00000157343
Uniprot IDs
P49638
Q5T9G4
PDB IDs
1OIP
1OIZ
1R5L
5MUE
5MUG
6ZPD
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling
Low-density Lipoprotein Particle
Very-low-density Lipoprotein Particle
Lipoprotein Lipase Activator Activity
High-density Lipoprotein Particle
Intermediate-density Lipoprotein Particle
Intermediate Filament
Lipoprotein Metabolic Process
Keratin Filament
Positive Regulation Of Triglyceride Catabolic Process
Trans-Golgi Network Membrane
Triglyceride-rich Lipoprotein Particle Remodeling
Chylomicron
Phospholipid Efflux
Small Molecule Biosynthetic Process
Carboxylic Acid Biosynthetic Process
Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
Intramolecular Oxidoreductase Activity, Transposing C=C Bonds
Gamma-aminobutyrate Shunt
Glutamate Decarboxylase Activity
Negative Regulation Of Establishment Of Blood-brain Barrier
Sebaceous Gland Cell Differentiation
4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity
Free Fatty Acid 2-hydroxylase Activity
Glucosylceramide Biosynthetic Process
Fatty Acid 2-hydroxylase Activity
Regulation Of Sebum Secreting Cell Proliferation
Regulation Of Acinar Cell Proliferation
Monocarboxylic Acid Metabolic Process
Fatty Acid Biosynthetic Process
CAF-1 Complex
Regulation Of Establishment Of Blood-brain Barrier
Vitamin E Binding
Central Nervous System Myelin Maintenance
Organic Acid Metabolic Process
Lyase Activity
Carboxylic Acid Metabolic Process
Lipid Modification
Enoyl-CoA Hydratase Activity
(3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
Delta(3)-delta(2)-enoyl-CoA Isomerase Activity
3-hydroxyacyl-CoA Dehydratase Activity
Cytosol
Gamma-aminobutyric Acid Biosynthetic Process
L-glutamate Catabolic Process
Gamma-aminobutyric Acid Metabolic Process
Succinate Metabolic Process
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
DNA Replication-dependent Chromatin Assembly
NURF Complex
Retromer, Tubulation Complex
Lamellipodium Morphogenesis
Leptin Receptor Binding
Vitamin E Metabolic Process
Positive Regulation Of Amyloid-beta Clearance
SUMO-specific Endopeptidase Activity
DeSUMOylase Activity
Regulation Of DNA Endoreduplication
Galactosylceramide Biosynthetic Process
Galactosylceramide Metabolic Process
Glucosylceramide Metabolic Process
Peripheral Nervous System Myelin Maintenance
Carboxylic Acid Catabolic Process
Carbon-carbon Lyase Activity
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