MYBL1 and NLK

Number of citations of the paper that reports this interaction (PubMedID 16055500)
53

Data Source:
BioGRID (enzymatic study)

		MYBL1	NLK
Description		MYB proto-oncogene like 1	nemo like kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding SH2 Domain Binding Metal Ion Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding
	Biological Process	Mitotic Cell Cycle Regulation Of DNA-templated Transcription Male Meiosis I Spermatogenesis Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of PiRNA Transcription	MAPK Cascade Regulation Of DNA-templated Transcription Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Regulation Of Signal Transduction Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Cellular Response To Stress Intracellular Signal Transduction TORC1 Signaling Protein Stabilization Protein Localization To Lysosome Cellular Response To Osmotic Stress Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		PIWI-interacting RNA (piRNA) biogenesis	Ca2+ pathway
Drugs
Diseases
GWAS			Non-response to bupropion and depression ( 27622933)
Interacting Genes		4 interacting genes: CREBBP HIPK2 NCL NLK	27 interacting genes: ASGR1 ATXN1 CREBBP CUL1 FBXW5 FOXO4 FOXP3 GRN HIPK2 KRTAP10-1 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 NDOR1 NOTCH1 QRICH1 RCHY1 RPTOR SDR16C5 SKP2 STAT3 USP4 ZHX3
Entrez ID		4603	51701
HPRD ID		08868	17637
Ensembl ID		ENSG00000185697	ENSG00000087095
Uniprot IDs		P10243 Q495G0	Q9UBE8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Histone H3K18 Acetyltransferase Activity Intracellular Signaling Cassette N-terminal Peptidyl-lysine Acetylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Macropinosome Membrane Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Corepressor Activity Regulation Of Signal Transduction DNA Topoisomerase Binding Lens Induction In Camera-type Eye Wnt Signaling Pathway, Calcium Modulating Pathway MRF Binding Regulation Of DNA-templated Transcription Protein Stabilization Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Transcription Coactivator Activity Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Embryonic Retina Morphogenesis In Camera-type Eye PML Body Organization Voluntary Musculoskeletal Movement Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Hypoxia Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription By RNA Polymerase I Response To Oxygen Levels Response To Decreased Oxygen Levels Negative Regulation Of Signal Transduction PH Domain Binding Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Cell Communication Negative Regulation Of Signaling Virion Binding Protein Serine Kinase Activity Protein Phosphorylation Iris Morphogenesis Peptidyl-lysine Acetylation	Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intermediate Filament Response To Hypoxia Response To Decreased Oxygen Levels Positive Regulation Of RNA Metabolic Process Response To Oxygen Levels Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Developmental Process T-helper 17 Type Immune Response Regulation Of Cell Development Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Cytosol Regulation Of Glial Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Cell Development Positive Regulation Of Cell Differentiation Negative Regulation Of Interleukin-4 Production Positive Regulation Of Odontoblast Differentiation RNA Polymerase II Transcription Regulator Complex Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Interleukin-5 Production Positive Regulation Of Neuroepithelial Cell Differentiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Regulation Of DNA-templated Transcription Cellular Response To Stress Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Odontoblast Differentiation
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