NCAM2 and CTNND2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		NCAM2	CTNND2
Description		neural cell adhesion molecule 2	catenin delta 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Nuclear Body Axon Neuron Projection Synaptic Membrane	Nucleus Cytoplasm Plasma Membrane Adherens Junction Postsynaptic Density Dendrite Cell Projection Perikaryon Anchoring Junction
	Molecular Function	Identical Protein Binding	Protein Binding Beta-catenin Binding Cadherin Binding
	Biological Process	Cell Adhesion Neuron Cell-cell Adhesion Axonal Fasciculation	Cell Adhesion Signal Transduction Wnt Signaling Pathway Synapse Organization Regulation Of Canonical Wnt Signaling Pathway Dendritic Spine Morphogenesis Cell-cell Adhesion
Pathways
Drugs
Diseases			Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
GWAS		Asthma ( 29273806) Blood protein levels ( 30072576) Colorectal or endometrial cancer ( 26621817) Diisocyanate-induced asthma ( 25918132) Endometrial cancer (endometrioid histology) ( 30093612) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HOMA-B (corrected for HOMA-IR) ( 30369944) Longevity ( 20834067) Metabolite levels ( 23823483) Obesity ( 21552555) Rosacea symptom severity ( 29771307) Venous thromboembolism ( 33592630) Visceral fat ( 22589738)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Cannabis dependence symptom count ( 27028160) Clostridioides difficle infection ( 33841421) Cognitive performance (processing speed) ( 31598132) Common carotid intima-media thickness in HIV infection ( 29206233) Corneal astigmatism ( 30306274) Facial emotion recognition ( 28608620) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Lewy body disease ( 25188341) Macular thickness ( 30535121) Myopia (pathological) ( 21095009) Pulse pressure ( 27841878) Refractive error ( 32231278) Response to antidepressants (symptom improvement) ( 29160301) Sensorimotor dexterity ( 31596458) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Systolic blood pressure ( 27841878) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		11 interacting genes: CHD4 CTNND2 FNDC3B PRNP RSPH1 SCG3 YWHAB YWHAE YWHAG YWHAH YWHAZ	22 interacting genes: ABL1 ATN1 CDH1 CDH2 CLK1 CTNNB1 CTTN ERBIN FYN LCK LNX1 LRRC7 MAGI2 NCAM2 NUDT21 PDZD2 PSEN1 PSEN2 PTGER4 SPHK1 TBKBP1 TTR
Entrez ID		4685	1501
HPRD ID		03619	09181
Ensembl ID		ENSG00000154654	ENSG00000169862
Uniprot IDs		O15394	A0A994J5V2 B4DJU1 B4DRK2 E7EPC8 Q9UQB3
PDB IDs		2DOC 2JLL 2KBG 2V5T 2VAJ 2WIM 2XY1 2XY2 2XYC
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding Protein Sequestering Activity Protein Domain Specific Binding Cerebellar Granule Cell To Purkinje Cell Synapse Transmembrane Transporter Binding Protein Targeting Cadherin Binding Melanosome Insulin-like Growth Factor Receptor Binding Histone Deacetylase Binding Focal Adhesion Regulation Of Protein Localization Dendritic Spine Organization Neuron Projection Organization Postsynapse Organization Regulation Of Synaptic Plasticity Negative Regulation Of Immune System Process Identical Protein Binding Intracellular Protein Localization Phosphoprotein Binding Protein Phosphatase Inhibitor Activity Substantia Nigra Development Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Regulation Of Synapse Organization Regulation Of Potassium Ion Transmembrane Transport Extracellular Exosome Type 8 Metabotropic Glutamate Receptor Binding Establishment Of Protein Localization Neural Nucleus Development Negative Regulation Of TORC1 Signaling TORC1 Signaling Glucocorticoid Catabolic Process Cytoplasm Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Regulation Of Heart Rate By Hormone TOR Signaling Synaptic Target Recognition Regulation Of Protein Stability Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of TOR Signaling RNA Binding Protein Phosphatase Binding Enzyme Binding Regulation Of TORC1 Signaling Protein Kinase C Inhibitor Activity Protein Localization To Secretory Granule	Postsynapse Cell Motility Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Junction Cell Adhesion Synapse Organization T Cell Activation Cell-cell Adhesion Glutamatergic Synapse Catenin Complex Cell-cell Junction T Cell Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Migration Anchoring Junction CD8 Receptor Binding Regulation Of Cell Projection Organization Positive Regulation Of Blood Vessel Branching Lymphocyte Activation Regulation Of Neuron Projection Development Protein Tyrosine Kinase Activity Cellular Response To Indole-3-methanol Cell-cell Adhesion Mediated By Cadherin Response To Indole-3-methanol Cell Junction Organization Detection Of Abiotic Stimulus Neuron Projection Organization Growth Factor Receptor Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving Cellular Response To Growth Factor Stimulus Detection Of Mechanical Stimulus Detection Of Muscle Stretch Gamma-secretase Complex Response To Xenobiotic Stimulus Thymus Development Receptor Clustering Positive Regulation Of Neuron Projection Development Intracellular Signal Transduction T Cell Differentiation Regulation Of Synapse Organization Antigen Receptor-mediated Signaling Pathway Regulation Of Blood Vessel Branching Adherens Junction Organization Fascia Adherens Cytoplasm Cadherin Binding Response To Growth Factor Fc Receptor Signaling Pathway Mononuclear Cell Differentiation Activated T Cell Proliferation
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