NCAM2 and CHD4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		NCAM2	CHD4
Description		neural cell adhesion molecule 2	chromodomain helicase DNA binding protein 4
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GO Annotations	Cellular Component	Plasma Membrane Membrane Nuclear Body Axon Neuron Projection Synaptic Membrane	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Membrane NuRD Complex Protein-containing Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage Cerebellar Granule Cell To Purkinje Cell Synapse
	Molecular Function	Identical Protein Binding	Nucleotide Binding Transcription Coregulator Binding DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Cell Adhesion Neuron Cell-cell Adhesion Axonal Fasciculation	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Chromatin Organization Chromatin Remodeling Negative Regulation Of Gene Expression Oxygen Transport Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Synapse Assembly Terminal Button Organization Regulation Of Stem Cell Differentiation
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Asthma ( 29273806) Blood protein levels ( 30072576) Colorectal or endometrial cancer ( 26621817) Diisocyanate-induced asthma ( 25918132) Endometrial cancer (endometrioid histology) ( 30093612) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HOMA-B (corrected for HOMA-IR) ( 30369944) Longevity ( 20834067) Metabolite levels ( 23823483) Obesity ( 21552555) Rosacea symptom severity ( 29771307) Venous thromboembolism ( 33592630) Visceral fat ( 22589738)	Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Myopia (pathological) ( 23049088)
Interacting Genes		11 interacting genes: CHD4 CTNND2 FNDC3B PRNP RSPH1 SCG3 YWHAB YWHAE YWHAG YWHAH YWHAZ	27 interacting genes: ATM ATR CDR1 CEBPA EP300 EPAS1 H2AC4 H2BC3 H3-4 H3C1 H4C1 HDAC1 HIF1A IKZF4 MTNR1A NCAM2 PSTPIP1 PTEN RNF8 RORC SMARCA4 SUMO2 TRIM27 TTN TWIST1 UBE2I XRN1
Entrez ID		4685	1108
HPRD ID		03619	04472
Ensembl ID		ENSG00000154654	ENSG00000111642
Uniprot IDs		O15394	A0A2U3TZM0 F5GWX5 Q14839
PDB IDs		2DOC 2JLL 2KBG 2V5T 2VAJ 2WIM 2XY1 2XY2 2XYC	1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG 6Q3M 6RYR 6RYU 8D4Y
Enriched GO Terms of Interacting Partners?		Phosphoserine Residue Binding Protein Sequestering Activity Protein Domain Specific Binding Cerebellar Granule Cell To Purkinje Cell Synapse Transmembrane Transporter Binding Protein Targeting Cadherin Binding Melanosome Insulin-like Growth Factor Receptor Binding Histone Deacetylase Binding Focal Adhesion Regulation Of Protein Localization Dendritic Spine Organization Neuron Projection Organization Postsynapse Organization Regulation Of Synaptic Plasticity Negative Regulation Of Immune System Process Identical Protein Binding Intracellular Protein Localization Phosphoprotein Binding Protein Phosphatase Inhibitor Activity Substantia Nigra Development Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Regulation Of Synapse Organization Regulation Of Potassium Ion Transmembrane Transport Extracellular Exosome Type 8 Metabotropic Glutamate Receptor Binding Establishment Of Protein Localization Neural Nucleus Development Negative Regulation Of TORC1 Signaling TORC1 Signaling Glucocorticoid Catabolic Process Cytoplasm Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transport Regulation Of Metal Ion Transport Regulation Of Heart Rate By Hormone TOR Signaling Synaptic Target Recognition Regulation Of Protein Stability Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of TOR Signaling RNA Binding Protein Phosphatase Binding Enzyme Binding Regulation Of TORC1 Signaling Protein Kinase C Inhibitor Activity Protein Localization To Secretory Granule	Chromatin Remodeling DNA Binding Chromatin Organization Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Heterodimerization Activity Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Structural Constituent Of Chromatin Negative Regulation Of Macromolecule Metabolic Process Chromosome, Telomeric Region Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coregulator Binding Negative Regulation Of Metabolic Process Chromosome PML Body Nucleus Nucleosome Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Circadian Rhythm Nucleosome Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Rhythmic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Double-strand Break Repair SUMO Transferase Activity Positive Regulation Of Macromolecule Metabolic Process P53 Binding Negative Regulation Of RNA Metabolic Process Histone H2AXS139 Kinase Activity Negative Regulation Of T Cell Apoptotic Process Epithelial Cell Maturation Regulation Of Transcription By RNA Polymerase II Embryonic Placenta Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression
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