SEPTIN9 and MYO1C

Number of citations: 66 (PubMedID 30975701)
Data Source: BioGRID (affinity chromatography technology, pull down)

		SEPTIN9	MYO1C
Name		septin 9	myosin IC
Structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton Microtubule Cilium Axoneme Septin Ring Actin Cytoskeleton Microtubule Cytoskeleton Septin Complex Cell Division Site Intercellular Bridge Perinuclear Region Of Cytoplasm Non-motile Cilium	Stress Fiber Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Actin Filament Plasma Membrane Microvillus Brush Border Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Myosin Complex Unconventional Myosin Complex Nuclear Body Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Stereocilium Ruffle Membrane Cell Projection Membrane Raft Phagocytic Vesicle Stereocilium Membrane Extracellular Exosome B-WICH Complex Plasma Membrane Bounded Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Cadherin Binding Molecular Adaptor Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Small GTPase Binding Actin Filament Binding
	Biological Process	Intracellular Protein Localization Actin Cytoskeleton Organization Septin Cytoskeleton Organization Cell Division Cytoskeleton-dependent Cytokinesis Positive Regulation Of Non-motile Cilium Assembly	Chromatin Remodeling Protein Targeting To Membrane Endocytosis Actin Filament Organization Actin Filament-based Movement Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Type II Interferon Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cellular Response To Insulin Stimulus Regulation Of Bicellular Tight Junction Assembly
Pathways		None	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis
Diseases		Hereditary neuralgic amyotrophy (HNA); Hereditary brachial plexus neuropathy	None
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 30061737 ) Mean platelet volume ( 32888494 ) Neutrophil count ( 32888494 ) Pulse pressure ( 30578418 ) White blood cell count ( 32888494 )
Novel Interactors		None recorded	1 novel interactors: MYH10
Interacting Genes		21 interacting genes: APP CEBPA HIF1A HNRNPD HSF2BP IKBKG LINC00839 LINC01554 MYO1C MYO6 NEDD4 PIN1 PLK1 PTPRF RAB10 SEPTIN1 SEPTIN11 SEPTIN2 SEPTIN6 SEPTIN7 STK11	11 interacting genes: BAZ1B CBL CDC42 KHDRBS1 NEIL3 PTEN RBFOX2 RBPMS RRN3 SEPTIN9 WEE2-AS1
Entrez ID		10801	4641
HPRD ID		10360	09411
Ensembl ID		ENSG00000184640	ENSG00000197879
Uniprot IDs		A0A0S2Z5A5 Q9UHD8	F5H6E2 O00159
PDB IDs		4YQF 5CYO 5CYP	4BYF
GO Terms Enriched among Interactors		Septin Ring Septin Complex Cell Division Site Cytoskeleton-dependent Cytokinesis Midbody Sperm Annulus Positive Regulation Of Catabolic Process Microtubule Cytoskeleton GTPase Activity Intracellular Protein Localization Molecular Adaptor Activity Positive Regulation Of Protein Metabolic Process GTP Binding Phosphothreonine Residue Binding Cellular Response To Stress Nucleotide Binding Cell Division Organelle Localization Phosphoserine Residue Binding Unconventional Myosin Complex Cytoskeletal Motor Activity Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Nucleus Cleavage Furrow Response To Metal Ion Chromosome, Centromeric Region Kinetochore Cell Cortex Cell Projection Regulation Of Protein Localization Regulation Of Protein Catabolic Process Anoikis Positive Regulation Of Proteolysis Reproductive Process Positive Regulation Of Protein Catabolic Process Motile Cilium Intracellular Signal Transduction Protein Domain Specific Binding Stress Fiber Spindle Cellular Developmental Process Cytoplasm Cell Projection Organization Protein-containing Complex Spermatogenesis Male Gamete Generation Establishment Of Localization In Cell Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Organelle Localization DNA Damage Response	Regulation Of Alternative MRNA Splicing, Via Spliceosome Dendritic Spine Morphogenesis Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleus Localization Dendritic Spine Organization Nuclear Migration Molecular Function Inhibitor Activity Regulation Of RNA Splicing Protein Tyrosine Kinase Binding Neuron Projection Organization Postsynapse Organization Nucleic Acid Binding Establishment Of Organelle Localization Neuron Projection Morphogenesis Negative Regulation Of Synaptic Vesicle Clustering Histone H2AXY142 Kinase Activity Grb2-Sos Complex MRNA Binding MCM Complex Binding Cell Projection Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction GBD Domain Binding Storage Vacuole Fourth Ventricle Development Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity WICH Complex Negative Regulation Of Mitotic Chromosome Condensation Regulation Of MRNA Metabolic Process Neuron Projection Stress Fiber Positive Regulation Of Transport Endothelin Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Cytoskeleton-dependent Cytokinesis Myosin II Filament Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission RNA Polymerase I Core Binding SH3 Domain Binding Regulation Of Rap Protein Signal Transduction Actin Filament-based Process Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Chromosome Condensation