USP6 and ATXN7L3

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		USP6	ATXN7L3
Gene Name		ubiquitin specific peptidase 6	ataxin 7-like 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosome Plasma Membrane Recycling Endosome	SAGA Complex DUBm Complex
	Molecular Function	Nucleic Acid Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Rab GTPase Activator Activity Protein Binding Calmodulin Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Cellular Protein Modification Process Protein Deubiquitination Positive Regulation Of Rab GTPase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Proteasomal Protein Catabolic Process	Chromatin Organization Transcription, DNA-templated Histone Deubiquitination Positive Regulation Of Transcription, DNA-templated
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ANKRD44 APP ATXN7L3 CDC42 EXOSC8 MDFI MYL2 RAB33B RAC1	7 interactors: HIST2H2AC HIST2H2BE PICK1 SECISBP2 SERTAD1 UCHL3 USP6
Entrez ID		9098	56970
HPRD ID		06827	12507
Ensembl ID		ENSG00000129204	ENSG00000087152
Uniprot IDs		P35125	Q14CW9
PDB IDs			2KKT
Enriched GO Terms of Interacting Partners?		Organ Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Binding Regulation Of Kinase Activity Organ Development Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Lipid Kinase Activity Heart Contraction Positive Regulation Of DNA Replication Axon Guidance Negative Regulation Of Transport Regulation Of Protein Phosphorylation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of Cellular Protein Metabolic Process Blood Coagulation Hemostasis Regulation Of Intracellular Transport Regulation Of ERBB Signaling Pathway Negative Regulation Of Constitutive Secretory Pathway Muscle Cell Fate Specification Regulation Of Synapse Structure Or Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Ephrin Receptor Signaling Pathway Cellular Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Axonogenesis System Development Cellular Protein Localization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hair Follicle Cell Proliferation Regulation Of Cell Projection Assembly Positive Regulation Of JNK Cascade Positive Regulation Of Cell-substrate Adhesion Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Regulation Of DNA Replication Vesicle-mediated Transport Wound Healing
Tagcloud ?		abc aneurysmal attenuates atypical augmented autoimmunity canonical classical cyst distinguishing dysregulated ikappab ikk ikkalpha ikkbeta ikkgamma involve nemo nih3t3 overexpressed precipitates s536 translocated tre17 tumorigenic ubiquitinating uncover unexpected	acetyltransferase activators coactivators cofactor cofactors counteract dense deubiquitinase deubiquitination drosophila enhancer eny2 gcn5 h2a h2b hat heterochromatin loci loosening mda metazoan module necessary pol precise staga tftc usp22 variegation
Tagcloud (Difference) ?		abc aneurysmal attenuates atypical augmented autoimmunity canonical classical cyst distinguishing dysregulated ikappab ikk ikkalpha ikkbeta ikkgamma involve nemo nih3t3 overexpressed precipitates s536 translocated tre17 tumorigenic ubiquitinating uncover unexpected	acetyltransferase activators coactivators cofactor cofactors counteract dense deubiquitinase deubiquitination drosophila enhancer eny2 gcn5 h2a h2b hat heterochromatin loci loosening mda metazoan module necessary pol precise staga tftc usp22 variegation
Tagcloud (Intersection) ?