LSS and TMEM167B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LSS	TMEM167B
Description		lanosterol synthase	transmembrane protein 167B
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Lanosterol Synthase Activity Protein Binding Isomerase Activity Intramolecular Transferase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability	Constitutive Secretory Pathway
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		R048-8071 Lanosterol
Diseases
GWAS		Glutathione peroxidase in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) White blood cell count ( 27863252)	Apolipoprotein B levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A	33 interacting genes: ACKR2 AGPAT3 APOL3 AQP10 AQP6 ASPH C14orf180 CD300C CD47 CTXN3 EBP FXYD6-FXYD2 HSD17B11 HSD17B13 LETMD1 LSS MGST2 PLLP REEP4 SACM1L SEC22B SERINC2 SLC34A3 SLC71A2 SMPD2 STX12 STX1B TAS2R19 TM4SF19 TMEM100 TMEM107 UNC50 ZDHHC21
Entrez ID		4047	56900
HPRD ID		02945	16474
Ensembl ID		ENSG00000160285	ENSG00000215717
Uniprot IDs		B2R694 P48449	A0A494C0V7 Q9NRX6
PDB IDs		1W6J 1W6K
Enriched GO Terms of Interacting Partners?		Bile Acid:sodium Symporter Activity Nitrate Transmembrane Transporter Activity Bile Acid And Bile Salt Transport Cytoplasmic Side Of Nuclear Pore Positive Regulation Of Male Germ Cell Proliferation Peptidyl-lysine Demalonylation Protein Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein-malonyllysine Demalonylase Activity D-lysine 5,6-aminomutase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Response To Ischemia PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Chemokine-mediated Signaling Pathway Protein-glutaryllysine Deglutarylase Activity Protein-succinyllysine Desuccinylase Activity Protein Deglutarylation Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Nuclear Pore Symporter Activity Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane MRNA Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Male Germ Cell Proliferation Histone Deacetylase Activity, NAD-dependent Monocarboxylic Acid Transport	Membrane Endoplasmic Reticulum Steroid Dehydrogenase Activity Lipid Droplet SNAP Receptor Activity Lipid Metabolic Process Water Channel Activity Lipid Biosynthetic Process Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity
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