LSS and MX2

Data Source: HiPPIP (Novel)

		LSS	MX2
Name		lanosterol synthase	MX dynamin like GTPase 2
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Cytosol Microtubule Plasma Membrane Synapse Presynapse
	Molecular Function	Lanosterol Synthase Activity Protein Binding Isomerase Activity Intramolecular Transferase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability	Immune System Process Defense Response Response To Virus Protein Transport Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Interferon-alpha Innate Immune Response Regulation Of Nucleocytoplasmic Transport MRNA Transport Defense Response To Virus Regulation Of Cell Cycle
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs		R048-8071 Lanosterol	None
GWAS		Glutathione peroxidase in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683 ) White blood cell count ( 27863252 )	Cutaneous malignant melanoma ( 32341527 ) Melanoma ( 21983787 28212542 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Parkinson disease and lewy body pathology ( 25663231 ) Tau burden ( 33426524 )
Novel Interactors		3 novel interactors: MX2 NUP214 SIRT5	6 novel interactors: IGFBP4 LSS MX1 NDUFV3 PKNOX1 STK38L
Interacting Genes		9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A	3 interacting genes: ATRIP EHMT2 PIAS2
Entrez ID		4047	4600
HPRD ID		02945	01001
Ensembl ID		ENSG00000160285	ENSG00000183486
Uniprot IDs		B2R694 P48449	P20592
PDB IDs		1W6J 1W6K	4WHJ 4X0R 5UOT
GO Terms Enriched among Interactors		Bile Acid:sodium Symporter Activity Nitrate Transmembrane Transporter Activity Bile Acid And Bile Salt Transport Cytoplasmic Side Of Nuclear Pore Positive Regulation Of Male Germ Cell Proliferation Peptidyl-lysine Demalonylation Protein Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein-malonyllysine Demalonylase Activity D-lysine 5,6-aminomutase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Response To Ischemia PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Chemokine-mediated Signaling Pathway Protein-glutaryllysine Deglutarylase Activity Protein-succinyllysine Desuccinylase Activity Protein Deglutarylation Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Nuclear Pore Symporter Activity Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane MRNA Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Male Germ Cell Proliferation Histone Deacetylase Activity, NAD-dependent Monocarboxylic Acid Transport	None