LSS and SLC10A6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LSS	SLC10A6
Description		lanosterol synthase	solute carrier family 10 member 6
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Plasma Membrane Membrane
	Molecular Function	Lanosterol Synthase Activity Protein Binding Isomerase Activity Intramolecular Transferase Activity	Protein Binding Bile Acid:sodium Symporter Activity Symporter Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability	Monoatomic Ion Transport Sodium Ion Transport Lipid Transport Bile Acid And Bile Salt Transport Sodium-dependent Organic Anion Transport Transmembrane Transport
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	SLC-mediated bile acid transport
Drugs		R048-8071 Lanosterol
Diseases
GWAS		Glutathione peroxidase in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683) White blood cell count ( 27863252)	Eyebrow thickness ( 26926045) Insulin-related traits ( 22791750) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A	175 interacting genes: ACSL5 AGPAT4 AIG1 ANKRD46 APOD ARL6IP1 ARLN ARV1 ATP13A1 BMP10 BTN2A2 C11orf24 C14orf180 C2CD2L C3orf52 CATSPERH CCDC167 CCL4 CDIPT CDS1 CFTR CLDND2 CMTM5 CNIH1 COL4A5 COMT COX20 CTSA CXCL16 CYB5B CYB5R3 CYP4F2 DERL1 DGAT2L6 EBP EMC6 ERG28 FA2H FAM3C FAXDC2 FIS1 FKBP8 FMO1 FUNDC2 FXYD3 FXYD6 FXYD6-FXYD2 GIMAP1 GIMAP5 GJB2 GJB6 GLB1 GOLT1B GOSR2 GPR151 GYPA GYPC HMOX1 HTATIP2 IGFBP5 ITGAM JAGN1 LPAR3 LSS MALL MFSD6 MGLL MS4A1 MS4A13 NAT8 NEU1 NINJ2 NRM OR7D4 ORMDL1 OSMR PEDS1-UBE2V1 PEX16 PIP4P1 PIP4P2 PLLP PLP1 PLP2 PNLIPRP1 PRAF2 PRRT2 PSEN1 PSENEN RNF24 RTP2 RUSF1 SACM1L SCAMP4 SCAMP5 SCD SEC22B SELENOK SERP1 SERP2 SFT2D2 SFXN1 SLC12A7 SLC25A46 SLC29A2 SLC30A2 SLC30A3 SLC35B4 SLC35G2 SLC35H1 SLC38A1 SLC38A7 SLC39A6 SLC39A9 SLC41A1 SLC61A1 SLC66A2 SLC7A1 SMAGP SMCO4 SMIM1 SNORC STATH STX12 STX3 STX7 STX8 SYNGR1 SYNJ2BP TAP1 TECR TF THBD TM4SF4 TMEM107 TMEM11 TMEM119 TMEM120B TMEM128 TMEM143 TMEM14A TMEM14B TMEM14C TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM242 TMEM243 TMEM252 TMEM50B TMEM60 TMEM65 TMEM86A TMEM86B TPRG1 TRARG1 TREX1 TSNARE1 TSPAN2 TSPO2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP3 VAMP4 YIPF1 YIPF2 YIPF6 ZDHHC15 ZFPL1
Entrez ID		4047	345274
HPRD ID		02945	11593
Ensembl ID		ENSG00000160285	ENSG00000145283
Uniprot IDs		B2R694 P48449	Q3KNW5
PDB IDs		1W6J 1W6K
Enriched GO Terms of Interacting Partners?		Bile Acid:sodium Symporter Activity Nitrate Transmembrane Transporter Activity Bile Acid And Bile Salt Transport Cytoplasmic Side Of Nuclear Pore Positive Regulation Of Male Germ Cell Proliferation Peptidyl-lysine Demalonylation Protein Demalonylation Protein Desuccinylation Peptidyl-lysine Desuccinylation Protein-malonyllysine Demalonylase Activity D-lysine 5,6-aminomutase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Response To Ischemia PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Chemokine-mediated Signaling Pathway Protein-glutaryllysine Deglutarylase Activity Protein-succinyllysine Desuccinylase Activity Protein Deglutarylation Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Nuclear Pore Symporter Activity Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane MRNA Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Male Germ Cell Proliferation Histone Deacetylase Activity, NAD-dependent Monocarboxylic Acid Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Endomembrane System Protein Binding SNARE Complex Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Sterol Biosynthetic Process Lipid Metabolic Process Lipid Biosynthetic Process Membrane Fusion Establishment Of Protein Localization Membrane Organization Vesicle Docking Membrane Docking Vesicle-mediated Transport Golgi Membrane Mitochondrial Outer Membrane Plasma Membrane Organelle Localization By Membrane Tethering Golgi Apparatus Cholesterol Biosynthetic Process Transmembrane Transport Steroid Biosynthetic Process Amino Acid Transmembrane Transport Chloride Channel Inhibitor Activity Sterol Metabolic Process SNARE Binding Golgi Trans Cisterna Synaptic Vesicle Membrane Zinc Ion Transmembrane Transporter Activity Golgi Medial Cisterna Transport Vesicle Vesicle Organization Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity Alkenylglycerophosphocholine Hydrolase Activity Protein Transport Intracellular Chemical Homeostasis Structural Constituent Of Myelin Sheath Zinc Ion Transmembrane Transport Cellular Localization Zinc Ion Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Transport Chemical Homeostasis Small Molecule Biosynthetic Process
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