MUSK and SYNE1

Number of citations of the paper that reports this interaction (PMID 10878022)
63

Data Source:
HPRD (in vivo)

		MUSK	SYNE1
Gene Name		muscle, skeletal, receptor tyrosine kinase	spectrin repeat containing, nuclear envelope 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell Junction Neuromuscular Junction Receptor Complex Postsynaptic Membrane	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Golgi Apparatus Cytoskeleton Integral Component Of Membrane Sarcomere Nuclear Membrane LINC Complex Postsynaptic Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Actin Binding Protein Binding Lamin Binding Protein Homodimerization Activity Poly(A) RNA Binding Actin Filament Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Neuromuscular Junction Development Memory Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation	Nucleus Organization Golgi Organization Establishment Of Nucleus Localization Muscle Cell Differentiation Cytoskeletal Anchoring At Nuclear Membrane Nuclear Matrix Anchoring At Nuclear Membrane
Pathways		ECM proteoglycans	Meiotic synapsis
Drugs
Diseases
GWAS		Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 21926972 21738484) Bipolar disorder and major depressive disorder (combined) ( 20351715) Tonometry ( 17903302)
Protein-Protein Interactions		4 interactors: COLQ DOK7 RAPSN SYNE1	15 interactors: ACTC1 APC CAPN1 CDC42 CDC5L CEP63 DISC1 DTNBP1 EMD KIAA0368 LMNA MUSK NDEL1 SH3BP5 TNIK
Entrez ID		4593	23345
HPRD ID		03190	09762
Ensembl ID		ENSG00000030304	ENSG00000131018
Uniprot IDs		O15146	Q8NF91
PDB IDs			4DXR
Enriched GO Terms of Interacting Partners?		Synaptic Transmission, Cholinergic Receptor Clustering Neuromuscular Junction Development Protein Localization Positive Regulation Of Neuromuscular Synaptic Transmission Synapse Organization Acetylcholine Catabolic Process In Synaptic Cleft Nuclear Matrix Anchoring At Nuclear Membrane Regulation Of Postsynaptic Membrane Organization Nuclear Matrix Organization Acetylcholine Catabolic Process Cellular Protein Localization Protein Localization To Membrane Skeletal Muscle Acetylcholine-gated Channel Clustering Cytoskeletal Anchoring At Nuclear Membrane Neurotransmitter Catabolic Process Maintenance Of Protein Location In Nucleus Synaptic Transmission Cellular Localization Asymmetric Protein Localization Establishment Of Nucleus Localization Neurotransmitter Metabolic Process Postsynaptic Membrane Organization Positive Regulation Of Protein Tyrosine Kinase Activity Membrane Organization Nucleus Localization Cell-cell Signaling Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Death Golgi Organization	Cytoskeleton Organization Endomembrane System Organization Microtubule-based Process Nuclear Envelope Disassembly Organelle Organization Microtubule Cytoskeleton Organization Cell Differentiation Membrane Organization Nuclear Envelope Organization Regulation Of Cell Projection Organization Mitotic Nuclear Envelope Reassembly Wnt Signaling Pathway Cell Cycle Process Regulation Of Synapse Organization Nuclear Envelope Reassembly Regulation Of Synapse Structure Or Activity Canonical Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Phosphorylation Striated Muscle Tissue Development Mitotic Cell Cycle Process Muscle Tissue Development Nucleus Organization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cellular Component Organization Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Cell Cycle Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Establishment Or Maintenance Of Cell Polarity Regulation Of Signaling Cardiac Muscle Tissue Development Generation Of Neurons Muscle Structure Development Mitotic Nuclear Envelope Disassembly System Development Regulation Of Cellular Localization Neurogenesis Cellular Localization
Tagcloud ?		amine butylacetophenone butylxylene centrilobular cosmetics cyp1a cyp2b cyp3a cytochromes dinitro dosed equimolar gavage isozymes ketone microsomes mk musks mx nitroaromatic nitromusk noel observable p450 perfume phenobarbital toiletries trinitro xylene	aimed cdna controls correlation distributed encompasses esr1 follicular genotyped genotyping investigating menstrual menstrually migraine mm mrm pgr plink pmm potentially pure qpcr rs3093664 rs9371601 rstudio snps tnf undertaking variants
Tagcloud (Difference) ?		amine butylacetophenone butylxylene centrilobular cosmetics cyp1a cyp2b cyp3a cytochromes dinitro dosed equimolar gavage isozymes ketone microsomes mk musks mx nitroaromatic nitromusk noel observable p450 perfume phenobarbital toiletries trinitro xylene	aimed cdna controls correlation distributed encompasses esr1 follicular genotyped genotyping investigating menstrual menstrually migraine mm mrm pgr plink pmm potentially pure qpcr rs3093664 rs9371601 rstudio snps tnf undertaking variants
Tagcloud (Intersection) ?