MUSK and COLQ

Number of citations of the paper that reports this interaction (PMID 15159418)
17

Data Source:
HPRD (in vivo)

		MUSK	COLQ
Gene Name		muscle, skeletal, receptor tyrosine kinase	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell Junction Neuromuscular Junction Receptor Complex Postsynaptic Membrane	Collagen Trimer Basal Lamina Extracellular Space Cell Junction Synapse
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Neuromuscular Junction Development Memory Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation	Acetylcholine Catabolic Process In Synaptic Cleft Asymmetric Protein Localization
Pathways		ECM proteoglycans
Drugs
Diseases
GWAS		Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Protein-Protein Interactions		4 interactors: COLQ DOK7 RAPSN SYNE1	3 interactors: ACHE BCHE MUSK
Entrez ID		4593	8292
HPRD ID		03190	04328
Ensembl ID		ENSG00000030304	ENSG00000206561
Uniprot IDs		O15146	Q9Y215
PDB IDs			1VZJ
Enriched GO Terms of Interacting Partners?		Synaptic Transmission, Cholinergic Receptor Clustering Neuromuscular Junction Development Protein Localization Positive Regulation Of Neuromuscular Synaptic Transmission Synapse Organization Acetylcholine Catabolic Process In Synaptic Cleft Nuclear Matrix Anchoring At Nuclear Membrane Regulation Of Postsynaptic Membrane Organization Nuclear Matrix Organization Acetylcholine Catabolic Process Cellular Protein Localization Protein Localization To Membrane Skeletal Muscle Acetylcholine-gated Channel Clustering Cytoskeletal Anchoring At Nuclear Membrane Neurotransmitter Catabolic Process Maintenance Of Protein Location In Nucleus Synaptic Transmission Cellular Localization Asymmetric Protein Localization Establishment Of Nucleus Localization Neurotransmitter Metabolic Process Postsynaptic Membrane Organization Positive Regulation Of Protein Tyrosine Kinase Activity Membrane Organization Nucleus Localization Cell-cell Signaling Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Death Golgi Organization	Negative Regulation Of Synaptic Transmission Cellular Biogenic Amine Metabolic Process Amine Metabolic Process Positive Regulation Of Protein Geranylgeranylation Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Receptor Biosynthetic Process Cocaine Metabolic Process Synapse Organization Acetylcholine Catabolic Process Acetylcholine Catabolic Process In Synaptic Cleft Neuroblast Differentiation Learning Or Memory Cognition Regulation Of Synaptic Growth At Neuromuscular Junction Regulation Of Synaptic Transmission Receptor Biosynthetic Process Alcohol Metabolic Process Regulation Of Synaptic Transmission, Cholinergic Choline Metabolic Process Neurotransmitter Receptor Metabolic Process Single-organism Behavior Skeletal Muscle Acetylcholine-gated Channel Clustering Alkaloid Metabolic Process Neurotransmitter Catabolic Process Response To Folic Acid Synaptic Transmission, Cholinergic Behavior Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Cell Differentiation Phosphatidylcholine Biosynthetic Process Neurotransmitter Metabolic Process Regulation Of Receptor Recycling Osteoblast Development Postsynaptic Membrane Organization Drug Metabolic Process Receptor Internalization Receptor Clustering Neuromuscular Junction Development Phosphatidylcholine Metabolic Process Neurological System Process Negative Regulation Of Signaling Regulation Of Synapse Assembly Positive Regulation Of Neuron Apoptotic Process Multicellular Organismal Development Positive Regulation Of Neuron Death Synapse Assembly Receptor Metabolic Process Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity
Tagcloud ?		amine butylacetophenone butylxylene centrilobular cosmetics cyp1a cyp2b cyp3a cytochromes dinitro dosed equimolar gavage isozymes ketone microsomes mk musks mx nitroaromatic nitromusk noel observable p450 perfume phenobarbital toiletries trinitro xylene	accomplished acetylcholinesterase ache ageing aldohexose bche butyrylcholinesterase characterised cholinergic cholinesterase d2m dibucaine hand1 hyper medicinal mega modeled ngf nlgn2 ortho pathwaylinker perceptive phosphomotifs retinol string trigliceridaemia unravelling upgma usinf
Tagcloud (Difference) ?		amine butylacetophenone butylxylene centrilobular cosmetics cyp1a cyp2b cyp3a cytochromes dinitro dosed equimolar gavage isozymes ketone microsomes mk musks mx nitroaromatic nitromusk noel observable p450 perfume phenobarbital toiletries trinitro xylene	accomplished acetylcholinesterase ache ageing aldohexose bche butyrylcholinesterase characterised cholinergic cholinesterase d2m dibucaine hand1 hyper medicinal mega modeled ngf nlgn2 ortho pathwaylinker perceptive phosphomotifs retinol string trigliceridaemia unravelling upgma usinf
Tagcloud (Intersection) ?