SYNE1 and AKAP12

		SYNE1	AKAP12
Description		spectrin repeat containing nuclear envelope protein 1	A-kinase anchoring protein 12
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Membrane Neuronal Cell Body Schaffer Collateral - CA1 Synapse
	Molecular Function	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity	Protein Binding Calmodulin Binding Adenylate Cyclase Binding Protein Kinase A Binding
	Biological Process	Nucleus Organization Golgi Organization Spermatogenesis Cell Differentiation Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Kinase A Signaling Positive Regulation Of Protein Kinase A Signaling Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Hepatic Stellate Cell Activation Negative Regulation Of Vascular Permeability Modulation Of Chemical Synaptic Transmission Response To Electrical Stimulus Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Regulation Of Protein Kinase C Signaling Positive Regulation Of Oligodendrocyte Apoptotic Process
Pathways		Meiotic synapsis	RHOD GTPase cycle RHOF GTPase cycle
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Emery-Dreifuss muscular dystrophy
GWAS		Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 20351715 21738484 21926972 34002096 28072414 28115744 31043756) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 30194396 31249589 31649266)	Alzheimer's disease progression score ( 29860282) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Chronic myeloid leukemia ( 21540461) Coronary artery disease ( 29212778) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Delirium ( 29631748) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Nevus count or cutaneous melanoma ( 32341527) Refractive error ( 32231278) Type 2 diabetes ( 25760438) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		28 interacting genes: ACTC1 APC BDKRB2 BTG3 CAPN1 CDC42 CDC5L CEP63 DISC1 DSCAM DSCR9 DTNBP1 ECPAS EMD ITSN1 LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 PCNT SH3BP5 TNIK TP53RK USP21 USP7 XIAP	9 interacting genes: ADRB2 CDK1 EGFR ERBB2 GRK2 PLK1 PRKAR2A PRKCA PTEN
Entrez ID		23345	9590
HPRD ID		09762	05263
Ensembl ID		ENSG00000131018	ENSG00000131016
Uniprot IDs		A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91	Q02952 Q86TJ9
PDB IDs		4DXR 6R15 6XF2
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Cytotoxicity Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Postsynapse Organization Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Cytoskeleton Organization Regulation Of Synapse Organization Microtubule Organizing Center Molecular Adaptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Radial Glia-guided Pyramidal Neuron Migration Antigen Processing And Presentation Centrosome Regulation Of T Cell Mediated Immunity Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell Cycle Natural Killer Cell Mediated Immunity Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leading Edge Membrane Positive Regulation Of Lymphocyte Mediated Immunity Glutamatergic Synapse Regulation Of Dendritic Spine Development Positive Regulation Of Adaptive Immune Response Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cytoskeleton Neuron Projection Morphogenesis Cytosol Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Leukocyte Mediated Cytotoxicity Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Regulation Of Protein Localization	Mitotic Nuclear Membrane Disassembly Membrane Disassembly Nuclear Membrane Disassembly Protein Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Activity Enzyme Binding Nuclear Membrane Organization Regulation Of Mitotic Cell Cycle Nucleotide Binding ERBB2-EGFR Signaling Pathway Regulation Of Growth Intracellular Signal Transduction Anaphase-promoting Complex Binding Negative Regulation Of Multicellular Organismal Process Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Protein Phosphorylation Symbiont Entry Into Host Cell Golgi Organization ATP Binding Phosphorylation Positive Regulation Of Mitotic Cell Cycle Protein Serine/threonine Kinase Activity Negative Regulation Of Muscle Contraction Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Phase Transition Regulation Of Protein Localization Positive Regulation Of Protein Localization Negative Regulation Of Programmed Cell Death ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Biological Process Involved In Interaction With Host Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Site Of Double-strand Break Regulation Of Cellular Component Organization Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Excitatory Postsynaptic Potential Receptor Complex Identical Protein Binding Transferase Activity Regulation Of Cell Cycle Positive Regulation Of Epithelial Cell Proliferation Central Nervous System Neuron Axonogenesis Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of System Process Negative Regulation Of Mitotic Cell Cycle
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