SYNE1 and ZC3H12D

		SYNE1	ZC3H12D
Description		spectrin repeat containing nuclear envelope protein 1	zinc finger CCCH-type containing 12D
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane	P-body Nucleus Nucleoplasm Cytoplasm Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity	MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Nucleus Organization Golgi Organization Spermatogenesis Cell Differentiation Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane	Negative Regulation Of Cell Growth 3'-UTR-mediated MRNA Destabilization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Meiotic synapsis
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Emery-Dreifuss muscular dystrophy
GWAS		Appendicular lean mass ( 33097823) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 20351715 21738484 21926972 34002096 28072414 28115744 31043756) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 30194396 31249589 31649266)	Asthma ( 32296059) Dupuytren's disease ( 21732829 28886342) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		28 interacting genes: ACTC1 APC BDKRB2 BTG3 CAPN1 CDC42 CDC5L CEP63 DISC1 DSCAM DSCR9 DTNBP1 ECPAS EMD ITSN1 LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 PCNT SH3BP5 TNIK TP53RK USP21 USP7 XIAP	1 interacting genes: ZC3H12A
Entrez ID		23345	340152
HPRD ID		09762	19272
Ensembl ID		ENSG00000131018	ENSG00000178199
Uniprot IDs		A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91	A2A288
PDB IDs		4DXR 6R15 6XF2
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Cytotoxicity Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Postsynapse Organization Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Cytoskeleton Organization Regulation Of Synapse Organization Microtubule Organizing Center Molecular Adaptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Radial Glia-guided Pyramidal Neuron Migration Antigen Processing And Presentation Centrosome Regulation Of T Cell Mediated Immunity Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell Cycle Natural Killer Cell Mediated Immunity Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leading Edge Membrane Positive Regulation Of Lymphocyte Mediated Immunity Glutamatergic Synapse Regulation Of Dendritic Spine Development Positive Regulation Of Adaptive Immune Response Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cytoskeleton Neuron Projection Morphogenesis Cytosol Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Leukocyte Mediated Cytotoxicity Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Regulation Of Protein Localization	P-body Nuclear Matrix Organization Cytoskeleton-nuclear Membrane Anchor Activity Nuclear Matrix Anchoring At Nuclear Membrane Cellular Response To Sodium Arsenite Positive Regulation Of Protein Deubiquitination Cellular Response To Salt Response To Sodium Arsenite Positive Regulation Of MiRNA Catabolic Process Negative Regulation Of Cardiac Muscle Contraction Cellular Response To Ionomycin Meiotic Nuclear Membrane Microtubule Tethering Complex Lamin Binding Regulation Of Protein Deubiquitination Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of T-helper 17 Cell Differentiation Cellular Response To Chemokine Rough Endoplasmic Reticulum Membrane Negative Regulation Of Macrophage Activation Host-mediated Suppression Of Viral Genome Replication RNA Stem-loop Binding Negative Regulation Of Striated Muscle Contraction MiRNA Catabolic Process RNA Exonuclease Activity Cellular Response To Arsenic-containing Substance Cellular Response To Ether Negative Regulation Of T-helper 17 Type Immune Response 3'-UTR-mediated MRNA Destabilization Negative Regulation Of Heart Contraction Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Lipid Storage Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Muscle Contraction Negative Regulation Of Blood Circulation MiRNA Metabolic Process Response To Ether Response To Salt Maintenance Of Protein Location In Nucleus Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of P38MAPK Cascade Regulation Of T-helper 17 Cell Differentiation MRNA 3'-UTR AU-rich Region Binding RNA Nuclease Activity Response To Arsenic-containing Substance Negative Regulation Of Alpha-beta T Cell Differentiation Nuclear Outer Membrane Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Interleukin-1 Production
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